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	Provedor de dados BJMBR (2) Autor Yin,Min (2) Cui,Yan (1) Li,Na (1) Liu,Feng (1) Liu,Jingang (1) Wang,Mofei (1) Wang,Yong (1) Xu,Jian (1) Yin,Jiajun (1) Mais... Palavra-chave Chronic kidney disease (1) Diabetes mellitus (1) FXR (1) Long non-coding RNAs (1) MAFB (1) Obesity (1) Prognostic biomarkers (1) Sleeve gastrectomy (1) WGCNA (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2018 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Screening potential prognostic biomarkers of long non-coding RNAs for predicting the risk of chronic kidney disease BJMBR Li,Na; Cui,Yan; Yin,Min; Liu,Feng. Not much is known about the roles of long non-coding RNAs (lncRNAs) for chronic kidney disease (CKD). In this study, we included CKD patient cohorts and normal controls as a discovery cohort to identify putative lncRNA biomarkers associated with CKD. We first compared the lncRNA expression profiles of CKD patients with normal controls, and identified differentially expressed lncRNAs and mRNAs. Co-expression network based on the enriched differentially expressed mRNAs and lncRNAs was constructed using WGCNA to identify important modules related to CKD. A lncRNA-miRNA-mRNA pathway network based on the hub lncRNAs and mRNAs, related miRNAs, and overlapping pathways was further constructed to reveal putative biomarkers. A total of 821 significantly... Tipo: Info:eu-repo/semantics/article Palavras-chave: Long non-coding RNAs; Chronic kidney disease; WGCNA; Prognostic biomarkers. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001100608 MAFB mediates the therapeutic effect of sleeve gastrectomy for obese diabetes mellitus by activation of FXR expression BJMBR Xu,Jian; Wang,Yong; Yin,Jiajun; Yin,Min; Wang,Mofei; Liu,Jingang. Farnesoid X receptor (FXR) and related pathways are involved in the therapeutic effect of sleeve gastrectomy for overweight or obese patients with diabetes mellitus. This study aimed to investigate the mechanism of FXR expression regulation during the surgical treatment of obese diabetes mellitus by sleeve gastrectomy. Diabetic rats were established by combined streptozotocin and high-fat diet induction. Data collection included body weight, chemical indexes of glucose and lipid metabolism, liver function, and the expression levels of musculoaponeurotic fibrosarcoma oncogene family B (MAFB), FXR, and related genes induced by sleeve gastrectomy. Chang liver cells overexpressing MAFB gene were established to confirm the expression of related genes. The... Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes mellitus; Obesity; Sleeve gastrectomy; MAFB; FXR. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000700612 Registros recuperados: 2 Primeira ... 1 ... Última

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