Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJMBR (2) Autor Zambelli,J.E. (2) Carvalho,C.R.O. (1) Francisco-DoPrado,J. (1) Lima,M.H.M. (1) Melo-Lima,M.H. (1) Ribeiro-DaSilva,G. (1) Saad,M.J.A. (1) Mais... Palavra-chave Blood glucose alterations (1) Canatoxin (1) Concanavalin A (1) Endogenous opioids (1) Hyperinsulinemia (1) Insulin action (1) Insulin receptor substrate (1) Phosphotyrosine phosphatase (1) SHPTP2 (1) Sex hormones (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 1998 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The insulin receptor substrate 1 associates with phosphotyrosine phosphatase SHPTP2 in liver and muscle of rats BJMBR Lima,M.H.M.; Zambelli,J.E.; Carvalho,C.R.O.; Saad,M.J.A.. Insulin stimulates the tyrosine kinase activity of its receptor resulting in the phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1) which, in turn, associates with proteins containing SH2 domains. It has been shown that IRS-1 associates with the tyrosine phosphatase SHPTP2 in cell cultures. While the effect of the IRS-1/SHPTP2 association on insulin signal transduction is not completely known, this association may dephosphorylate IRS-1 and may play a critical role in the mitogenic actions of insulin. However, there is no physiological demonstration of this pathway of insulin action in animal tissues. In the present study we investigated the ability of insulin to induce association between IRS-1 and SHPTP2 in liver and muscle... Tipo: Info:eu-repo/semantics/other Palavras-chave: Insulin action; Insulin receptor substrate; Phosphotyrosine phosphatase; SHPTP2. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001100007 The hyperinsulinemia produced by concanavalin A in rats is opioid-dependent and hormonally regulated BJMBR Francisco-DoPrado,J.; Zambelli,J.E.; Melo-Lima,M.H.; Ribeiro-DaSilva,G.. The present study examines the effect of concanavalin A (Con A) on the blood insulin and glucose levels of rats. Male and female rats treated with Con A (62.5-500 µg/kg) for three days showed a dose- and time-dependent hyperinsulinemia that lasted more than 48 h. Male rats were more sensitive to Con A. Thus, 6 h after treatment with Con A the circulating insulin levels in male rats had increased by 85% (control: 10.2 ± 0.9 mU/l and Con A-treated: 18.8 ± 1 mU/l) compared to only 38% (control: 7.5 ± 0.2 mU/l; Con A-treated: 10.3 ± 0.9 mU/l) in females. An identical response was seen after 12 h. Con A (250 µg/kg) produced time-dependent hypoglycemia in both sexes but more pronounced in males. There was no correlation between the hypoglycemia and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Concanavalin A; Hyperinsulinemia; Blood glucose alterations; Sex hormones; Endogenous opioids; Canatoxin. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000500015 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco