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| Lugo-Lugo,Daniela Elizabeth; Pozos-Guillén,Amaury de Jesús; Zapata-Morales,Juan Ramón; Rodríguez-Chong,Antonio; Rangel-López,Azahel de Jesús; Saavedra-Leos,María Zenaida; Vértiz-Hernández,Angel Antonio. |
| Eugenol has been employed for decades as a condiment, an antimycotic, an antibacterial, an antiviral, and an antioxidant, and it is one of the natural analgesics most frequently utilized for pain and inflammation. Our objective was to determine the analgesic/anti-inflammatory effect of eugenol compared with diclofenac, naproxen, and tramadol using the formalin test. The formalin method was used in 6- to 10-week-old Wistar rats (weighing 250 g each) divided into six groups: saline (0.9%); formalin (5%); diclofenac (250 µg/kg); naproxen (400 µg/kg); tramadol (500 µg/kg), and eugenol (1,400 µg/kg), in the intraplantar part of the hind-end trunk of the rats, with n = 5 per group. Eugenol diminished 44.4% of nociceptive behavior in phase 1 and 48% in phase 2 (p... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Eugenol/analgesic/anti-inflammatory effect; Diclofenac effect; Antinociception; Formalin test; Pain. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100536 |
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