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	Provedor de dados J. Venom. Anim. Toxins incl. Trop. Dis. (4) Autor Zare Mirakabadi,A (4) Ghorbanpur,M (2) Koohi,MK (2) Zokaee,F (2) Zolfagarrian,H (2) Boroumand,MA (1) Kassaaian,SE (1) Mahdavi,S (1) Purkabireh,M (1) Rabbani,SH (1) Rabiei,H (1) Sadeghian,S (1) Sotoudeh Anvari,M (1) Taghavian,M (1) Zayerzadeh,E (1) Mais... Palavra-chave Agkistrodon halys (2) Chromatography (2) Anticancer (1) Anticoagulant factor (1) Coagulant activity (1) Cytotoxic (1) Electrocardiogram changes (1) Histopathological changes (1) Iranian snake (1) MDA-MB-231 (1) Mesobuthus eupeus (1) Necrosis (1) Scorpion experimental envenomation (1) Serine protease (1) Snake venom (1) Troponin (1) Venom (1) Venom peptides (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2010 (2) 2009 (1) 2008 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Identification and partial purification of an anticoagulant factor from the venom of the Iranian snake Agkistrodon halys J. Venom. Anim. Toxins incl. Trop. Dis. Ghorbanpur,M; Zare Mirakabadi,A; Zokaee,F; Zolfagarrian,H. An anticoagulant factor was purified from the venom of the Iranian snake Agkistrodon halys by gel filtration on Sephadex G-50 and ion-exchange chromatography on DEAE-Sepharose. In the final stage of purification, the percentage recovery of purified anticoagulant factor was found to be 83%. The purified anticoagulant factor revealed a single protein band in SDS-polyacrylamide electrophoresis under reducing conditions and its molecular weight was about 22 kDa. The purified peptide did not show any effect on casein, BApNA or plasma. Tipo: Info:eu-repo/semantics/article Palavras-chave: Snake venom; Agkistrodon halys; Anticoagulant factor; Chromatography. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000100010 Cytotoxic effect of ICD-85 (venom-derived peptides) on MDA-MB-231 cell line J. Venom. Anim. Toxins incl. Trop. Dis. Zare Mirakabadi,A; Mahdavi,S; Koohi,MK; Taghavian,M. Since 1987, when chemopreventive testing programs began, more than 1,000 agents and agent combinations have been selected and evaluated in preclinical studies of chemopreventive activity against various types of cancers. In the present study we aimed to provide quantitative and qualitative characterization of biological and pharmacological activities of ICD-85 on MDA-MB-231 cell line (a highly invasive breast cancer cell line) in order to gain a better understanding of the cytotoxic and apoptotic effects of this compound. For this study, the MDA-MB-231 cell line was used and the effect of ICD-85 was assayed by measuring the activity of the cytosolic enzyme lactate dehydrogenase (LDH), released into the culture medium after membrane damage. Morphological... Tipo: Info:eu-repo/semantics/article Palavras-chave: Venom peptides; MDA-MB-231; Anticancer; Necrosis; Cytotoxic. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000400005 Purification and partial characterization of a coagulant serine protease from the venom of the Iranian snake Agkistrodon halys J. Venom. Anim. Toxins incl. Trop. Dis. Ghorbanpur,M; Zare Mirakabadi,A; Zokaee,F; Zolfagarrian,H; Rabiei,H. Agkistrodon halys is one of several dangerous snake species in Iran. Among the most important signs and symptoms in patients envenomated by this snake is disseminated intravascular coagulation. A thrombin-like enzyme, called AH143, was isolated from Agkistrodon halys venom by gel filtration on a Sephadex G-50 column, ion-exchange chromatography on a DEAE-Sepharose and high performance liquid chromatography (HPLC) on a C18 column. In the final stage of purification, 0.82 mg of purified enzyme was obtained from 182.5 mg of venom. The purified enzyme showed a single protein band by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), under reducing conditions, and its molecular mass was found to be about 30 kDa. AH143 revealed clotting... Tipo: Info:eu-repo/semantics/article Palavras-chave: Iranian snake; Venom; Agkistrodon halys; Serine protease; Chromatography; Coagulant activity. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300005 Cardiopulmonary complications induced by Iranian Mesobuthus eupeus scorpion venom in anesthetized rabbits J. Venom. Anim. Toxins incl. Trop. Dis. Zayerzadeh,E; Koohi,MK; Zare Mirakabadi,A; Purkabireh,M; Kassaaian,SE; Rabbani,SH; Sotoudeh Anvari,M; Boroumand,MA; Sadeghian,S. Scorpion envenomation is a life-threatening condition, especially in children and elderly individuals affected by respiratory and cardiovascular diseases. In this study, the toxic effects of median lethal dose (LD50) injections of Mesobuthus eupeus (Me) venom on the heart and lungs of anesthetized rabbits were investigated. Six rabbits were selected and alterations in their electrocardiogram, heart rate, respiration and blood pressure before and after venom injection were recorded. Cardiac troponin T (cTnT), creatinine kinase muscle-brain fraction (CK-MB) and lactate dehydrogenase (LDH) were measured at 0, 1 and 3 hours after envenomation and pathology studies were carried out postmortem. All the animals showed signs and symptoms of envenomation within 40... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mesobuthus eupeus; Scorpion experimental envenomation; Histopathological changes; Electrocardiogram changes; Troponin. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000100006 Registros recuperados: 4 Primeira ... 1 ... Última

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