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	Provedor de dados Genet. Mol. Biol. (2) Autor Liu,Yunqiang (2) Ma,Yongxin (2) Tao,Dachang (2) Zhang,Sizhong (2) Deng,Wenqian (1) Lu,Yongjie (1) Sun,Huaqin (1) Yang,Yuan (1) Mais... Palavra-chave Development (1) Kctd14 (1) Knockout mice (1) Rnf141 (1) Spermatogenesis (1) Zebrafish (Danio rerio) (1) Zinc finger protein (1) Znf230 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 2009 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Molecular cloning and expression analysis of a zebrafish novel zinc finger protein gene rnf141 Genet. Mol. Biol. Deng,Wenqian; Sun,Huaqin; Liu,Yunqiang; Tao,Dachang; Zhang,Sizhong; Ma,Yongxin. ZNF230 is a novel zinc finger gene cloned by our laboratory. In order to understand the potential functions of this gene in vertebrate development, we cloned the zebrafish orthologue of human ZNF230, named rnf141. The cDNA fragment of rnf141 was obtained by rapid amplification of cDNA ends (RACE). The open reading frame (ORF) encodes a polypeptide of 222 amino acids which shares 75.65% identity with the human ZNF230. RT-PCR analysis in zebrafish embryo and adult tissues revealed that rnf141 transcripts are maternally derived and that rnf141 mRNA has a broad distribution. Zygotic rnf141 message is strongly localized in the central nervous system, as shown by whole-mount in situ hybridization. Knockdown and over expression of rnf141 can induce abnormal... Tipo: Info:eu-repo/semantics/article Palavras-chave: Rnf141; Zebrafish (Danio rerio); Development; Zinc finger protein. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000300024 Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertility Genet. Mol. Biol. Liu,Yunqiang; Tao,Dachang; Lu,Yongjie; Yang,Yuan; Ma,Yongxin; Zhang,Sizhong. The mouse testis-enriched Znf230 gene, which encodes a type of RING finger protein, is present primarily in the nuclei of spermatogonia, the acrosome and the tail of spermatozoa. To investigate the role of Znf230 in spermatogenesis, we generated Znf230-deficient mice by disrupting Znf230 exon-5 and exon-6 using homologous recombination. The homozygous Znf230-knockout (KO) mice did not exhibit Znf230 mRNA expression and Znf230 protein production. Znf230 KO mice exhibited no obvious impairment in body growth or fertility. Male Znf230 KO mice had integral reproductive systems and mature sperm that were regular in number and shape. The developmental stages of male germ cells of Znf230 KO mice were also normal. We further examined variations in the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Znf230; Knockout mice; Spermatogenesis; Kctd14. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000500014 Registros recuperados: 2 Primeira ... 1 ... Última

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