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| Li,JinLong; Li,Hui; Zhang,ZhaoLi; Wang,NianYue; Zhang,Yong Chen. |
| CONTEXT: Trichosanthin produced in the root tube of Trichosanthes kirilowii shows anti-tumor activity on a series of cancer cells including Hela, MCF-7, HL-60. But there is little information about its effect on the carcinogenesis of prostate cancer. OBJECTIVE: This work was designed to study the role of trichosanthin on prostate cancer cells PC3. MATERIALS AND METHODS: Trichosanthin was expressed in BL21 strain and purified by affinity chromatography. MTT assay was designed to determine the effect of trichosanthin on growth of PC3 cells at doses of 10, 20, 40, 60, 80, and 120 μg/ml.Then the effect of 50 μg/ml rTCS alone or combined with 2 μΜ IL-2 on PC3 cell proliferation was analyzed. And the mechanism of rTCS was... |
| Tipo: Journal article |
Palavras-chave: Trichosanthin; Interleukin IL-2; Prostate cancer cells PC3; Tumor. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100021 |
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