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	Provedor de dados BJMBR (3) Autor Zhao,J. (3) Cao,C. (1) He,Y.J. (1) Liang,Y. (1) Liu,S. (1) Lv,X. (1) Qiao,M. (1) Qin,L. (1) Shen,Y. (1) Shu,J.C. (1) Tang,Y. (1) Wang,L.X. (1) Wang,Q. (1) Wang,X.L. (1) Ye,G.R. (1) Yin,Q. (1) Zhao,J.R. (1) Mais... Palavra-chave Acute colitis (1) Apoptosis (1) Curcumin (1) Hepatic fibrosis (1) Hepatic stellate cells (1) Inflammation (1) Lymphangiogenesis (1) Marker (1) Microvessel density (1) Pancreatic ductal adenocarcinoma (1) Proliferation (1) TGF-β1 (1) VEGF-C (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2016 (2) 2009 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Clinical and prognostic significance of serum transforming growth factor-beta1 levels in patients with pancreatic ductal adenocarcinoma BJMBR Zhao,J.; Liang,Y.; Yin,Q.; Liu,S.; Wang,Q.; Tang,Y.; Cao,C.. Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of 5%. Biomarkers for the early detection of pancreatic cancer are urgently needed. Transforming growth factor-beta1 (TGF-β1) is elevated in the tissues and plasma of patients with PDAC. However, no studies systemically report prognostic significance of plasma TGF-β1 levels in PDAC. In the present study, we assessed the prognostic significance of serum TGF-β levels in patients with PDAC. TGF-β levels were determined in serum from 146 PDAC patients, and 58 patients with benign pancreatic conditions. Regression models were used to correlate TGF-β levels to gender, age, stage, class, and metastasis. Survival analyses were performed using multivariate Cox models. Serum levels of TGF-β1... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pancreatic ductal adenocarcinoma; Marker; TGF-β1. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000800705 Promoting inflammatory lymphangiogenesis by vascular endothelial growth factor-C (VEGF-C) aggravated intestinal inflammation in mice with experimental acute colitis BJMBR Wang,X.L.; Zhao,J.; Qin,L.; Qiao,M.. Angiogenesis and lymphangiogenesis are thought to play a role in the pathogenesis of inflammatory bowel diseases (IBD). However, it is not understood if inflammatory lymphangiogenesis is a pathological consequence or a productive attempt to resolve the inflammation. This study investigated the effect of lymphangiogenesis on intestinal inflammation by overexpressing a lymphangiogenesis factor, vascular endothelial growth factor-C (VEGF-C), in a mouse model of acute colitis. Forty eight-week-old female C57BL/6 mice were treated with recombinant adenovirus overexpressing VEGF-C or with recombinant VEGF-C156S protein. Acute colitis was then established by exposing the mice to 5% dextran sodium sulfate (DSS) for 7 days. Mice were evaluated for disease activity... Tipo: Info:eu-repo/semantics/article Palavras-chave: Inflammation; Lymphangiogenesis; Microvessel density; Acute colitis; VEGF-C. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000500602 Effect of curcumin on the proliferation and apoptosis of hepatic stellate cells BJMBR Shu,J.C.; He,Y.J.; Lv,X.; Zhao,J.R.; Zhao,J.; Shen,Y.; Ye,G.R.; Wang,L.X.. This study was designed to investigate the effect of curcumin (diferuloylmethane) on the proliferation and apoptosis of hepatic stellate cells (HSC). The cell line HSC-T6 (1.25 x 10(5) cells/mL) was incubated with curcumin and HSC proliferation was detected by a methyl thiazolyl tetrazolium colorimetric assay. HSC apoptosis was detected by flow cytometry, transmission electron microscope and agarose gel electrophoresis. HSC proliferation was significantly inhibited in a concentration-dependent manner (10.6 to 63.5%) after incubation with 20-100 μM curcumin, compared with a control group. At 20, 40, and 60 μM, after 24 h of incubation, curcumin was associated with a significant increase in the number of HSC in the G2/M phase, and a significant decrease in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Curcumin; Hepatic stellate cells; Proliferation; Apoptosis; Hepatic fibrosis. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200009 Registros recuperados: 3 Primeira ... 1 ... Última

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