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	Provedor de dados BJPS (3) Autor Cao,Guangxiang (3) Zhong,Chuanqing (3) Jin,Xiaoqing (2) Wang,Fengshan (2) Chen,Yuguo (1) Cheng,Yanna (1) Huang,Xiaojing (1) Wang,Liang (1) Zhang,Shu (1) Zhang,Xiaoxiao (1) Mais... Palavra-chave Clavulanic acid (1) Clavulanic acid/formation of the Related substance E (1) Heparin-superoxide dismutase conjugate (1) High Performance Liquid Chromatography-Mass Spectrometry-Mass Spectrometry (1) Oxidative stress injury (1) Potassium clavulanate (1) Potassium clavulanate/production (1) Radiation-induced damage (1) Related substance E/formation (1) Related substance E/forming mechanism High performance liquid chromatography/biotechnological process (1) Related substance G (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2017 (1) 2015 (1) 2014 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última The radiation protection role of heparin-SOD conjugate in irradiated mice BJPS Zhong,Chuanqing; Huang,Xiaojing; Zhang,Shu; Cheng,Yanna; Cao,Guangxiang; Wang,Fengshan. ABSTRACT Heparin-SOD conjugate (Hep-SOD) was prepared by modifying Cu,Zn-SOD with heparin. An acute radiation-induced mouse injury model was constructed to study the radiation protection effects of Hep-SOD conjugate. Fifty-six mice were randomly divided into seven groups: (I) normal control group; (II) irradiated control group; (III) positive control group (amifostine group, 300 mg/kg); (IV) SOD group (35000 U/kg); (V) high dosage of Hep-SOD group (70000 U/kg); (VI) medium dosage of Hep-SOD group (35000 U/kg); (VII) low dosage of Hep-SOD group (17500 U/kg). Drugs were intraperitoneally injected into each mouse 1 h before radiation except for the normal control group. All the irradiated groups were irradiated with 6 Gy. Organ indices, haematopoietic... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heparin-superoxide dismutase conjugate; Radiation-induced damage; Oxidative stress injury. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400611 Studies on the formation and synthetic mechanism of related substance G in potassium clavulanate production BJPS Jin,Xiaoqing; Cao,Guangxiang; Zhang,Xiaoxiao; Chen,Yuguo; Wang,Liang; Zhong,Chuanqing. The objective of this study was to investigate the formation and synthetic mechanism of related substance G in potassium clavulanate production. The impurity in the potassium clavulanate final product, with a retention time of 13.5 min, was confirmed as related substance G by high performance liquid chromatography-mass spectrometry/mass spectrometry. Related substance G analysis during the production of clavulanic acid showed that this impurity could be synthesized during fermentation, and the amount increased with the fermentation time. Studies on its synthetic mechanism showed that L-tyrosine and succinic acid were the precursors for biosynthesis of related substance G in vivo. The reaction was deduced to be catalyzed by an enzyme. The enzyme was a type... Tipo: Info:eu-repo/semantics/article Palavras-chave: Potassium clavulanate; Clavulanic acid; Related substance G; Related substance G; High Performance Liquid Chromatography-Mass Spectrometry-Mass Spectrometry. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100077 Studies on the formation and forming mechanism of the related substance E in potassium clavulanate production by HPLC-MS/MS BJPS Zhong,Chuanqing; Cao,Guangxiang; Jin,Xiaoqing; Wang,Fengshan. The objective of this study was to investigate the formation and forming mechanism of the related substance E in potassium clavulanate production. The impurity with retention time of 11.1 min in potassium clavulanate final product was confirmed as the related substance E by high performance liquid chromatography with tandem mass spectrometric detection (HPLC-MS/MS).The related substance E analysis during the production of clavulanic acid showed that this impurity could be formed during both the fermentation and purification processes, especially in the later fermentation stage, filtration concentration and back-extraction procedure. Clavulanic acid was the precursor of the related substance E. Studies on its forming mechanism showed that the related... Tipo: Info:eu-repo/semantics/article Palavras-chave: Potassium clavulanate/production; Clavulanic acid/formation of the Related substance E; Related substance E/formation; Related substance E/forming mechanism High performance liquid chromatography/biotechnological process. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200391 Registros recuperados: 3 Primeira ... 1 ... Última

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