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	Provedor de dados Biocell (1) BJID (1) Autor Zhou,Liping (2) Ba,Jing (1) Chen,Jun (1) Chen,Tian (1) Chen,Xi (1) Chen,Zhifei (1) Guo,Xiaolin (1) Li,Yuanyuan (1) Xia,Wei (1) Xu,Bin (1) Xu,Shunqing (1) Zhao,Lianshuang (1) Mais... Palavra-chave Cell migration (1) DNA mutational analysis (1) Fluoroquinolones (1) Hyaluronic acid (1) Lamellipodia formation (1) Mycobacterium tuberculosis (1) Uropod formation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/report (1) Ano 2012 (1) 2010 (1) País Argentina (1) Brazil (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity Biocell Zhou,Liping; Guo,Xiaolin; Ba,Jing; Zhao,Lianshuang. CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration. Tipo: Info:eu-repo/semantics/report Palavras-chave: Cell migration; Lamellipodia formation; Uropod formation; Hyaluronic acid. Ano: 2010 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000200005 Characterization of gyrA and gyrB mutations and fluoroquinolone resistance in Mycobacterium tuberculosis clinical isolates from Hubei Province, China BJID Chen,Jun; Chen,Zhifei; Li,Yuanyuan; Xia,Wei; Chen,Xi; Chen,Tian; Zhou,Liping; Xu,Bin; Xu,Shunqing. OBJECTIVE: The study aimed to investigate gyrA and gyrB mutations in Mycobacterium tuberculosis (MTB) clinical strains from 93 patients with pulmonary tuberculosis in Hubei Province, China, and analyze the association between mutation patterns of the genes and ofloxacin resistance level. RESULTS: Among 93 MTB clinical isolates, 61 were ofloxacin-resistant by the proportion method, and 32 were ofloxacin-susceptible MDR-TB. No mutation in the gyrB gene was found in any MTB strains. In the 61 ofloxacin-resistant isolates, 54 mutations were observed in the gyrA gene. Only one mutation in the gyrA gene was found in ofloxacin-susceptible MDR-TB isolates. In this study, the mutation patterns of gyrA involved seven patterns of single codon mutation (A90V, S91P,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mycobacterium tuberculosis; Fluoroquinolones; DNA mutational analysis. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200005 Registros recuperados: 2 Primeira ... 1 ... Última

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