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	Provedor de dados BJMBR (1) Autor Hao,Y.-P. (1) Sun,L. (1) Wang,H.-Y. (1) Wang,L. (1) Zhang,J. (1) Zhu,Y.-P. (1) Zhuang,Y.-P. (1) Mais... Palavra-chave Cancer (1) Computed tomography (1) Mouse models (1) Patient-derived tumor xenografts (PDTX) (1) Percutaneous biopsy (1) X-ray (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Establishment of patient-derived tumor xenograft (PDTX) models using samples from CT-guided percutaneous biopsy BJMBR Zhuang,Y.-P.; Zhu,Y.-P.; Wang,H.-Y.; Sun,L.; Zhang,J.; Hao,Y.-P.; Wang,L.. This study aimed to investigate the feasibility of the establishment of a human cancer xenograft model using samples from computed tomography (CT)-guided percutaneous biopsy. Fresh tumor tissues obtained from 10 cancer patients by CT-guided percutaneous biopsy were subcutaneously inoculated into NOD-Prkdcem26Il2rgem26Nju (NCG) mice to establish human patient-derived tumor xenograft (PDTX) models. The formation of first and second generation xenografts was observed, and tumor volume was recorded over time. Tumor tissue consistency between the PDTX model and primary tumors in patients was compared using H&E staining and immunohistochemistry. Pharmacodynamic tests of clinically used chemotherapeutic drugs were conducted on second generation xenografts,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; Patient-derived tumor xenografts (PDTX); Computed tomography; X-ray; Percutaneous biopsy; Mouse models. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600705 Registros recuperados: 1 Primeira ... 1 ... Última

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