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| Registros recuperados: 1.286 | |
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| Lee,Sarah Hwa In; Barancelli,Giovana Verginia; Corassin,Carlos Humberto; Rosim,Roice Eliana; Coppa,Carolina Fernanda Sengling Cebin; Oliveira,Carlos Augusto Fernandes de. |
| ABSTRACT This study aimed to investigate the effect of peracetic acid (PAA, 0.5%) on adherent cells of three strains of Listeria monocytogenes strains belonging to serotypes 4b and 1/2b that had been previously isolated from the environment of a Brazilian cheese plant. The assays were conducted using polystyrene microplates and stainless steel coupons and the adhered cells were treated with PAA for 60, 120 and 180 s. On stainless steel, biofilms were partially inactivated by PAA after 60 s and almost 100% of the cells were damaged within 180 s using epifluorescence microscopy with LIVE/DEAD® staining. On polystyrene microplates, PAA decreased (P<0.05) biofilm biomass produced by the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Peracetic acid (PAA)/ biofilm/effects; L. monocytogenes; Dairy plants/Brazil. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300610 |
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| Jing,Wu; Zhong,Jia; Ping,Liang Jian; Yan,Liu Hong. |
| ABSTRACT To study what kind of role uric acid play on the relationship between oxidative Stress and inflammation in peripheral and cerebral system of oxonate-induced hyperuricemic rats. Twenty-six eight male Wistar rats were divided into two groups randomly. Potassium oxonate was used to establish hyperuricemic model for four weeks. In 2nd and 4th week, uric acid (UA) level, total superoxide dismutase (T-SOD), Gu,Zn-SOD activity and interleukin-1beta (IL-1β) concentration in serum were determined respectively. In 4th week, one hour after last PO treatment, five rats of every group were given Evans Blue to test blood-brain barrier (BBB) permeability. Other brains were obtained to analysis T-SOD, Gu,Zn-SOD activity and IL-1β concentration in cerebral system.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hyperuricemic Blood brain barrier Potassium oxonate Oxidative stress Inflammatory Total-SOD Gu; Zn-SOD IL-1β Pathological injury. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400620 |
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| Queiroz,Kelly Marques; Silva,Maria-Luiza Martins; Prado,Nathália Duque; Lima,Paulo Marcelo Andrade; Diniz,Rosiane Dias Lopes; César,Isabela Costa; Pianetti,Gerson Antônio; Santos,Daniel Assis. |
| The development of a specific agar diffusion bioassay for the quantitative determination of fluconazole formulated in capsules was carried out using a strain of Candida albicans ATCC 18804 as the test organism. A prospective validation of the method showed adequate linearity (r²=0.9995), precision (R.S.D. = 4.0% for intra-day and 4.5% for inter-day precision) and accuracy (mean recovery = 102.9%). High performance liquid chromatography was chosen as a comparison method for the fluconazole determination. The contents of fluconazole determined by both methods, for four capsule samples, showed a strong correlation, confirmed by Pearson's correlation coefficient value (r = 0.9884). The bioassay is a suitable method for both research and pharmaceutical industry... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fluconazole/quantitative determination; Microbiological assay/agar diffusion; High performance liquid chromatography. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400012 |
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| Sankari,Thaeer; Al-Hariri,Sahar. |
| The main objective of the present work was to enhance the solubility and dissolution rate of poorly water-soluble drug cefuroxime axetil (CA) by formulating it into solid dispersions (SDs) with water soluble carrier poloxamer 188. Different methods were employed to prepare the dispersion, such as: Solvent method (SM), Kneading method (KM), Melt evaporation method (MEM) and Physical mixture (PM) in different drug: carrier ratios 1:1, 1:2 and 1:3 (cefuroxime axetil: poloxamer 188). The physical mixture(s) and solid dispersion(s) were characterized for drug carrier interaction, drug content, solubility, dissolution rate, differential scanning calorimetry (DSC) and FT-IR study. The dissolution rate of the prepared solid dispersion systems was determined in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cefuroxime axetil/dissolution; Poloxamer 188; Solid dispersion. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400622 |
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| Rojas,John; González,Cesar; Rico,Carolina; Saez,Oswaldo. |
| Metformin hydrochloride is an antidiabetic agent which improves glucose tolerance in patients with type 2 diabetes and reduces basal plasma levels of glucose. In this study, a simplex centroid experimental design with 69 runs was used to select the best combination of some hydrophilic polymers that rendered a 24 h in-vitro release profile of metformin.HCl. The Korsmeyer-Peppas model was used to model the dissolution profiles since it presented the best fit to the experimental data. Further, a cubic model predicted the best formulation of metformin.HCl containing polyvinyl pyrrolidone, ethyl cellulose, hydroxypropyl methyl cellulose, carrageenan, sodium alginate, and gum arabic at 6.26, 68.7, 6.26, 6.26, 6.26 and 6.26 % levels, respectively. The validation... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Metformin/release profile; Metformin.HCl/modified release; Metformin.HCl/in-vitro evaluation; Hydrophilic polymers/influence; Hydrophilic polymers/drugs release; Korsmeyer-Peppas model/dissolution profiles. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300006 |
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| Oliveira,Camila Freitas de; Oliveira,Vinicius Bednarczuk; Bobek,Vanessa Barbosa; Rech,Katlin Suellen; Betim,Fernando Cesar Martins; Dias,Josiane de Fatima Gaspari; Zanin,Sandra Maria Warumby; Miguel,Obdulio Gomes; Miguel,Marilis Dallarmi. |
| Psychotria fractistipula L.B.Sm, R.M. Klein & Delprete (Rubiaceae) is found in the existing Atlantic Forest in the South of Brazil, in the Paraná and Santa Catarina States. The members of Rubiaceae are characterized chemically by the presence of alkaloids, some pharmacological properties of which include antifungal, antibacterial, analgesic, antioxidant, antimutagenic, and antiviral activities. In this study, we report the results of anatomical, morphological, and histochemical analyses of the leaves and stems of the Rubiaceae family member, P. fractistipula. The anatomical analysis involved of light microscopy and scanning electron microscopy. Morpho-anatomical and histochemical characterization were made using standard methodology. The isolated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Psychotria; Morpho-anatomical; Phytochemistry. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100565 |
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| Coutinho,Isabel Duarte; Cardoso,Claúdia Andréa Lima; Ré-Poppi,Nilva; Melo,Adriana Mestriner; Vieira,Maria do Carmo; Honda,Neli Kika; Coelho,Roberta Gomes. |
| The essential oils from Campomanesia adamantium (Cambess.) O. Berg leaves, collected in the reproductive (flowering and fruit-bearing) and vegetative stages, were characterized by GC-MS (Gas Chromatography-Mass Spectrometry). A total of 95 compounds of the essential oils were identified. In the reproductive stage (flowering) the major constituents were monoterpenes (limonene, α-pinene and β-pinene) while during the vegetative stage the major constituents were the sesquiterpenes (bicyclogermacrene and globulol). The essential oil of the reproductive stage shows high antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans, and all show moderate activity against Escherichia coli. The essential oils were also evaluated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Campomanesia adamantium/antioxidant activity; Campomanesia adamantium/antimicrobial activity; Guavira; Essential oil/caracterization. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400022 |
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| Giorgetti,Leandro; Issa,Michele Georges; Ferraz,Humberto Gomes. |
| The aim of this study was to evaluate the effect of dissolution medium, rotation speed and compaction pressure on the intrinsic dissolution rate (IDR) of the antihypertensive drug amlodipine besylate, using the rotating disk method. Accordingly, a fractional factorial design (33-1) was used, employing dissolution media (water, phosphate buffer pH 6.8 and HCl 0.1 M), rotation speed (50, 75 and 100 rpm), and compaction pressure (1000, 1500 and 2000 psi) as independent variables. The assays were randomized and statistically compared using the Statistica(r) 11 software program. Significance testing (ANOVA) indicated that the dissolution medium had a considerable impact on the IDR of amlodipine besylate. Analysis of the linear and quadratic components of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amlodipine besylate/intrinsic dissolution; Biopharmaceutical classification system; Drugs/experimental design; Antihypertensive drugs/Amlodipine besylate. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300513 |
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| Lima,Fernando Freitas de; Lescano,Caroline Honaiser; Oliveira,Elaine Florinda Rodrigues de; Fakhouri,Farayde Matta; Moraes,Izabel Cristina Freitas; Kassuya,Cândida Aparecida Leite; Sanjinez-Argandoña,Eliana Janet. |
| This study aimed microencapsulating Attalea phalerata Mart. oil, containing high carotenoid and phenolic compounds content, with Arabic gum and gelatin, using the complex coacervation method. The yield, efficiency, morphology of microcapsules and content of phenolic compounds, carotenoids and antioxidant activity in different processes conditions (concentration of the filling, temperature and agitation speed) were evaluated. The results showed 88% of yield, efficiency up to 70% and a characteristic size of microcapsules. The amount of carotenoids was high in crude oil (394.84 µg of carotenoids/g oil) and the microencapsulation tests showed amounts of 19.19 to 166.40 µg of carotenoids/g oil. The phenolic compounds in the crude oil were 20.73 mg GAE/g sample... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Carotenoids; Phenolic compounds; Antioxidant activity; Bioactive compounds; Bioactive maintenance. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100580 |
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| Budel,Jane Manfron; Duarte,Márcia do Rocio. |
| A identificação de espécies de Baccharis que são constituídas de cladódios, ou seja, caules alados, apresenta dificuldades até mesmo para especialistas em taxonomia vegetal. Baccharis microcephala e B. trimera pertencem ao grupo Trimera e são conhecidas vulgarmente como carquejas. Na medicina popular, é comum o uso de espécies aladas para a aplicação terapêutica como diurético, hepatoprotetor e digestivo. Baccharis trimera consta na F. Bras. IV e possui atividades antiinflamatória, analgésica, bacteriostática, bactericida e antidiabética. As espécies B. trimera e B. microcephala são freqüentemente confundidas e utilizadas pela população para as mesmas finalidades terapêuticas. Objetivou-se estudar a morfologia externa e a anatomia dos cladódios dessas... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Asteraceae; Baccharis microcephala; Baccharis trimera; Controle de qualidade; Morfoanatomia. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000100009 |
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| Registros recuperados: 1.286 | |
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