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	Provedor de dados BABT (1) BJM (1) Autor Araújo,P. V. (1) Becker,Ana Cláudia (1) Benetti,Cibele Nabhan (1) Cortés,M. E. (1) Dellagnelo,Viviane Aparecida (1) Pereira,Eduardo Manoel (1) Rodrigues,Patrik Oening (1) Silva,Marcos Antonio Segatto (1) Sinisterra,R. D. (1) Teixeira,K. I. R. (1) Wagner,Theodoro Marcel (1) Mais... Palavra-chave Β-cyclodextrin (2) Anti-inflammatory activity (1) Bioavailability (1) Chlorhexidine (1) Dexamethasone acetate (1) Membrane-drug interactions (1) Solubility (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 2012 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Pharmacodynamic and Pharmacokinetic Studies of β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice BABT Rodrigues,Patrik Oening; Becker,Ana Cláudia; Dellagnelo,Viviane Aparecida; Benetti,Cibele Nabhan; Pereira,Eduardo Manoel; Wagner,Theodoro Marcel; Silva,Marcos Antonio Segatto. The aim of this study was to evaluate the in vivo activity of the anti-inflammatory and analgesic effects of a suspension of the complex composed of dexamethasone acetate (DMA) with β-cyclodextrin in comparison to a suspension of the pure DMA. Solid complexes prepared by different methods were evaluated in pharmacodynamics and pharmacokinetics studies. The pharmacodynamic effect was investigated although the capacity of the inhibited the inflammation. Models of abdominal constriction, carrageenan-induced paw oedema and formalin induced licking were used. The study of the pharmacodynamic comparison of free DMA and products of β-CD:DMA demonstrated no significant difference in the majority of the tests performed. Plasma concentrations of DMA and DMA:β-CD... Tipo: Info:eu-repo/semantics/article Palavras-chave: Solubility; Dexamethasone acetate; Β-cyclodextrin; Bioavailability; Anti-inflammatory activity. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600887 Chlorhexidine: beta-cyclodextrin inhibits yeast growth by extraction of ergosterol BJM Teixeira,K. I. R.; Araújo,P. V.; Sinisterra,R. D.; Cortés,M. E.. Chlorhexidine (Cx) augmented with beta-cyclodextrin (β-cd) inclusion compounds, termed Cx:β-cd complexes, have been developed for use as antiseptic agents. The aim of this study was to examine the interactions of Cx:β-cd complexes, prepared at different molecular ratios, with sterol and yeast membranes. The Minimal Inhibitory Concentration (MIC) against the yeast Candida albicans (C.a.) was determined for each complex; the MICs were found to range from 0.5 to 2 µg/mL. To confirm the MIC data, quantitative analysis of viable cells was performed using trypan blue staining. Mechanistic characterization of the interactions that the Cx:β-cd complexes have with the yeast membrane and assessment of membrane morphology following exposure to Cx:β-cd complexes were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chlorhexidine; Β-cyclodextrin; Membrane-drug interactions. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000200047 Registros recuperados: 2 Primeira ... 1 ... Última

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