|
|
| Marques,Daniela A. Viana; Santos-Ebinuma,Valéria de Carvalho; Oliveira,Patrícia Maria Sobral de; Lima,Gláucia Manoella de Souza; Araújo,Janete M.; Lima-Filho,José L.; Converti,Attilio; Pessoa-Júnior,Adalberto; Porto,Ana L.F.. |
| The selection of new microorganisms able to produce antimicrobial compounds is hoped for to reduce their production costs and the side effects caused by synthetic drugs. Clavulanic acid is a β-lactam antibiotic produced by submerged culture, which is widely used in medicine as a powerful inhibitor of β-lactamases, enzymes produced by bacteria resistant to antibiotics such penicillin and cephalosporin. The purpose of this work was to select the best clavulanic acid producer among strains of Streptomyces belonging to the Microorganism Collection of the Department of Antibiotics of the Federal University of Pernambuco (DAUFPE). Initially, the strains were studied for their capacity to inhibit the action of β-lactamases produced by Klebsiella aerogenes ATCC... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Clavulanic acid; Β-lactamases inhibitor; Streptomyces screening; Submerged culture; Growth kinetics. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000300022 |
| |
