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	Provedor de dados Biocell (2) Autor Joubert,Annie (2) Laurens,Johannes (1) Lottering,Mona-Liza (1) Van Zyl,Hermia (1) Vorster,Chris (1) Palavra-chave 2-methoxyestradiol (2) Apoptosis (1) Autophagy (1) Breast cancer (1) Cancer (1) Estradiol metabolism (1) Sulphamoylated estradiol derivative (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2009 (1) País Argentina (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última C2- and C4-position 17β-estradiol metabolites and their relation to breast cancer Biocell Joubert,Annie; Van Zyl,Hermia; Laurens,Johannes; Lottering,Mona-Liza. C2- and C4-position 17β-estradiol metabolites play an important role in breast carcinogenesis. 2-Hydroxyestradiol and 4-hydroxyestradiol are implicated in tumorigenesis via two pathways. These pathways entail increased cell proliferation and the formation of reactive oxygen species that trigger an increase in the likelihood of deoxyribonucleic acid mutations. 2-Methoxyestradiol, a 17β-estradiol metabolite, however, causes induction of apoptosis in transformed and tumor cells; thus exhibiting an antiproliferative effect on tumor growth. The 4-hydroxyestradiol:2-methoxyestradiol and 2-hydroxyestradiol:2-methoxyestradiol ratios therefore ought to be taken into account as possible indicators of carcinogenesis. Tipo: Info:eu-repo/semantics/article Palavras-chave: Breast cancer; Estradiol metabolism; 2-methoxyestradiol. Ano: 2009 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452009000300001 In vitro effects of 2-methoxyestradiol-bis-sulphamate on cell growth, morphology and cell cycle dynamics in the MCF-7 breast adenocarcinoma cell line Biocell Vorster,Chris; Joubert,Annie. In the search for new and improved anticancer therapies, researchers have identified several potentially useful compounds. One of these agents is 2-methoxyestradiol-bis-sulphamate (2ME-BM), a sulphamoylated derivative of 2-methoxyestradiol. The objective of this study was to evaluate 2ME-BM's in vitro efficacy as antiproliferative agent in the MCF-7 breast adenocarcinoma cell line. Light- and fluorescent microscopy showed decreased cell density, increased apoptotic characteristics and significant ultrastructural aberrations indicative of autophagic cell death after 24 hours of exposure at a concentration of 0.4µM. In addition, mitotic indices revealed that 2ME-BM induces a G2M block. The latter was confirmed by flow cytometric analyses where increased... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; 2-methoxyestradiol; Sulphamoylated estradiol derivative; Apoptosis; Autophagy. Ano: 2010 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000200003 Registros recuperados: 2 Primeira ... 1 ... Última

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