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| Rizo,Walace Fraga; Ferreira,Luis Eduardo; Colnaghi,Vanessa; Martins,Juliana Simões; Franchi,Leonardo Pereira; Takahashi,Catarina Satie; Beleboni,Rene Oliveira; Marins,Mozart; Pereira,Paulo Sérgio; Fachin,Ana Lúcia. |
| Cancer has become a major public health problem worldwide and the number of deaths due to this disease is increasing almost exponentially. In the constant search for new treatments, natural products of plant origin have provided a variety of new compounds to be explored as antitumor agents. Tabernaemontana catharinensis is a medicinal plant that produces alkaloids with expressive antitumor activity, such as heyneanine, coronaridine and voacangine. The aim of present study was firstly to screen the cytotoxic activity of the indole alkaloids heyneanine, coronaridine and voacangine against HeLa (human cervix tumor), 3T3 (normal mouse embryo fibroblasts), Hep-2 (human laryngeal epithelial carcinoma) and B-16 (murine skin) cell lines by MTT... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 3T3; Apoptosis; Comet assay; Indole alkaloid; LDH. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000100015 |
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| Costa,Rodrigo Netto; Abreu,Clarice Lima do Canto; Presgrave,Rosaura Farias; Alves,Eloisa Nunes; Presgrave,Octavio Augusto França; Delgado,Isabella Fernandes. |
| The aim of this work was to determine the correlation between results obtained from the Draize test and from the Total Protein Content Determination (TPC) to assess the ocular irritancy potential of 20 shampoos. For TPC, two established cell lines (SIRC and 3T3) were used. The concentration that induced 50% inhibition relative to controls (IC50) was calculated for each product. Among shampoos tested with SIRC, only one had a false positive result. However, for the 3T3, three false-negative results were found. Pearson coefficient related to the in vivo value of maximum average score (MAS) was -0.58 (p=0.007) with SIRC and -0.73 (p=0.007) with 3T3. These results showed that the TPC assay was capable to predict the ocular irritant potential of shampoos, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Draize test; Ocular irritation; TPC; Shampoos; SIRC; 3T3. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600008 |
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