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| BOAVENTURA,MARIA AMÉLIA D.; XAVIER,LAURA F.W.; VIEIRA,HENRIETE S.; TAKAHASHI,JACQUELINE A.; NASCIMENTO JUNIOR,WILTON J.D.; ARAUJO,TAMIRES P.; COELHO,AMANDA C.S.. |
| ABSTRACT Thirteen natural products derivatives of hydroxyl amide class, three described for the first time, were synthesized by reaction of three indole acids and 3,4,5-trimethoxybenzoic acid with six different amino alcohols in the presence of triphenylphosphine and N-bromosuccinimide. The derivatives were tested against the Gram (+) bacteria Staphylococcus aureus and Bacillus cereus, Gram (-) Pseudomonas aeruginosa and Escherichia coli, besides the yeast Candida albicans. One of the compounds (7) was selectively active against C. albicans (91.3 ± 0.49% inhibition) showing a great potential as a new drug lead, since it was more active than the positive control, miconazole (88.7 ± 2.41% inhibition). Regarding bacterial... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acetylcholinesterase inhibition antimicrobial activity indole acid derivatives 3; 4; 5-trimethoxybenzoic acid derivatives. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000501945 |
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| MOLGÓ,JORDI; COLASANTE,CESARE; ADAMS,DANY S; JAIMOVICH,ENRIQUE. |
| In this short article we review muscle satellite cell characteristics and our studies in adult rodent muscle satellite cells in situ. Using confocal laser scanning microscopy and immunocytochemistry, a high level of IP3 receptor (IP3R) immunostaining was detected in satellite cells. These cells were identified by their peripheral position, their size, the shape of their nucleus, the paucity of the apparent cytoplasm, and the immunostaining with specific molecular markers such as a-actinin, the neural cell adhesion molecule (N-CAM) and desmin. High extracellular K+ (60 mM) induced long-lasting Ca2+ signalsin satellite cells in situ. We suggest that electrical activity stimulates IP3-associated Ca2+ signals that could act in concert with signaling pathways... |
| Tipo: Journal article |
Palavras-chave: Muscle satellite cells Inositol 1; 4; 5-trisphosphate receptors intracellular Ca2+ Signal transduction. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400019 |
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| STRAUB,STEPHEN V; WAGNER II,LARRY E; BRUCE,JASON I.E; YULE,DAVID I. |
| Calcium release via intracellular Ca2+ release channels is a central event underpinning the generation of numerous, often divergent physiological processes. In electrically non-excitable cells, this Ca2+ release is brought about primarily through activation of inositol 1,4,5-trisphosphate receptors and typically takes the form of calcium oscillations. It is widely believed that information is carried in the temporal and spatial characteristics of these signals. Furthermore, stimulation of individual cells with different agonists can generate Ca2+ oscillations with dramatically different spatial and temporal characteristics. Thus, mechanisms must exist for the acute regulation of Ca2+ release such that agonist-specific Ca2+... |
| Tipo: Journal article |
Palavras-chave: Inositol 1; 4; 5-trisphosphate receptor protein kinase A calcium signaling pancreatic acinar cells parotid acinar cells. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400013 |
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| Gedikli,Serap; Aytar,Pinar; Ünal,Arzu; Yamaç,Mustafa; Çabuk,Ahmet; Kolankaya,Nazif. |
| Lacasse is one of the extracellular enzymes excreted from white and brown rot fungi, which is involved in ligninolysis. In the present study, the effects of the addition of lacasse inducers to the medium on enhancement of enzyme production under conditions of submerged fermentation were researched. At first, a culture medium was selected suitable for lacasse production. To increase the production of lacasse using different inducers and to examine the ability of dechlorination, this article focuses on screen lacasse activity of 21 basidiomycetes isolates grown in five culture media. All inducers evaluated influenced lacasse activity positively except for gallic acid, mannitol, and malt extract for studied isolates. Our findings showed that lacasse activity... |
| Tipo: Journal article |
Palavras-chave: 2; 4; 5-trichlorophenol basidiomycetes dechlorination inducer lacasse. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582010000600006 |
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