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	Provedor de dados BJMBR (2) Anais da ABC (AABC) (1) Autor Mendez-Otero,R. (2) Santiago,M.F. (2) Freitas,G.R. de (1) Gubert,F. (1) MENDEZ-OTERO,ROSALIA (1) SANTIAGO,MARCELO F. (1) Zaverucha-do-Valle,C. (1) Mais... Palavra-chave 9-O-acetyl GD3 (3) Development (2) Gangliosides (2) Neurite outgrowth (2) Adult neurogenesis (1) Ganglioside (1) Glycolipid (1) Neural stem cells (1) Neuronal Migration (1) Neuronal migration (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2005 (1) 2003 (1) 2001 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Functional role of a glycolipid in directional movements of neurons Anais da ABC (AABC) MENDEZ-OTERO,ROSALIA; SANTIAGO,MARCELO F.. Migration of neurons from their site of origin to their final destination is a critical and universal step in the formation of the complex structure of the nervous system. The migratory process is thought to be governed in part by genetically and epigenetically defined sequences of signals which are interpreted by migrating cells. The molecular mechanisms that underlie neuronal migration have been the subject of intense investigation. As in other developmental processes, many molecules must participate in neuronal migration. Some molecules, such as cell adhesion molecules and motor proteins, may contribute to discrete steps in the migration act; others, like extracellular signaling molecules, may regulate the activation and/or termination of the migration... Tipo: Info:eu-repo/semantics/article Palavras-chave: Glycolipid; Ganglioside; 9-O-acetyl GD3; Neuronal Migration; Neurite outgrowth; Development. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000200007 Regulation and function of neurogenesis in the adult vertebrate brain BJMBR Mendez-Otero,R.; Zaverucha-do-Valle,C.; Gubert,F.; Freitas,G.R. de; Santiago,M.F.. Most adult tissues retain a reservoir of self-renewing, multipotent stem cells that can generate differentiated tissue components. Until recently, the brain was thought to be an exception to this rule and for many years the pervasive dogma of neurobiology relegated neurogenesis to the embryonic and earlier postnatal stages of development. The discovery of constant neuronal replacement in the adult brain has changed the way we think about neurological diseases and about the exploration of new strategies for brain repair. In this review we will explore the potential of adult neural stem cells and we will present some of our own work on this subject. We will also discuss the possibility that adult neurogenesis and neuronal replacement may also play a role in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Neural stem cells; Adult neurogenesis; 9-O-acetyl GD3; Gangliosides. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000012 Functional role of a specific ganglioside in neuronal migration and neurite outgrowth BJMBR Mendez-Otero,R.; Santiago,M.F.. Cell migration occurs extensively during mammalian brain development and persists in a few regions in the adult brain. Defective migratory behavior of neurons is thought to be the underlying cause of several congenital disorders. Knowledge of the dynamics and molecular mechanisms of neuronal movement could expand our understanding of the normal development of the nervous system as well as help decipher the pathogenesis of neurological developmental disorders. In our studies we have identified and characterized a specific ganglioside (9-O-acetyl GD3) localized to the membrane of neurons and glial cells that is expressed in regions of cell migration and neurite outgrowth in the developing and adult rat nervous system. In the present article we review our... Tipo: Info:eu-repo/semantics/article Palavras-chave: Neuronal migration; Gangliosides; Development; 9-O-acetyl GD3; Neurite outgrowth. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800006 Registros recuperados: 3 Primeira ... 1 ... Última

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