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Analysis of the presence of FLT3 gene mutation and association with prognostic factors in adult and pediatric acute leukemia patients BJPS
Burnatt,Graciele; Licínio,Marley Aparecida; Gaspar,Pâmela Cristina; Ferreira,Arthur Schveitzer; Reis,Manoela Lira; Moraes,Ana Carolina Rabello de; Sincero,Thaís Cristine Marques; Santos-Silva,Maria Cláudia.
ABSTRACT When the FLT3 gene is mutated, it originates a modified receptor with structural changes, which give survival advantage and malignant hematopoietic cell proliferation. Thus, the presence of mutations in this gene is considered an unfavorable prognostic factor. A total of 85 consecutive samples of newly diagnosed untreated patients with AL were included in the study after they provided their informed consent. FLT3 gene mutations were detected by PCR. For the pediatric group, a positive correlation was observed between WBC count and the presence of FLT3-ITD in patients with AML and ALL. Furthermore, children with AML who had the FLT3-ITD mutation showed a tendency to express CD34 in blast cells. In the adult group, the AML patients with FLT3-ITD who...
Tipo: Info:eu-repo/semantics/article Palavras-chave: FLT3-ITD/mutation; Acute leucemia/prognostic factors; Acute leucemia/adults patients; Acute leucemia/pediatric patients; AML; ALL; FLT3-D835..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200617
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Relationship of an hRAD54 gene polymorphism (2290 C/T) in an Ecuadorian population with chronic myelogenous leukemia Genet. Mol. Biol.
Paz-y-Miño,César; López-Cortés,Andrés; Muñoz,María José; Castro,Bernardo; Cabrera,Alejandro; Sánchez,María Eugenia.
The hRAD54 gene is a key member of the RAD52 epistasis group involved in repair of double-strand breaks (DSB) by homologous recombination (HR). Thus, alterations of the normal function of these genes could generate genetic instability, shifting the normal process of the cell cycle, leading the cells to develop into cancer. In this work we analyzed exon 18 of the hRAD54 gene, which has been previously reported by our group to carry a silent polymorphism, 2290 C/T (Ala730Ala), associated to meningiomas. We performed a PCR-SSCP method to detect the polymorphism in 239 samples including leukemia and normal control population. The results revealed that the 2290 C/T polymorphism has frequencies of 0.1 for the leukemia and 0.1 for the control group. These...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; Leukemia; CML; ALL; HRAD54; 2290 C/T polymorphism.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400009
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