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| Rasool,Shahid; Aziz-ur-Rehman,; Abbasi,Muhammad Athar; Siddiqui,Sabahat Z; Shah,Syed Adnan Ali. |
| ABSTRACT A series of molecules bearing multiple functional groups were synthesized to study their antibiotic effect against Gram-positive and Gram-negative bacteria and lipoxygenase activity as well. 2,4-Dimethylcarbolic acid (1) was refluxed with ethyl 2-bromoacetate to synthesize ethyl 2-(2,4-dimethylphenoxy)acetate (2). Compound 2 was converted to the corresponding hydrazide 3, again on refluxing with hydrazine. The compound 5-((2,4-dimethylphenoxy)methyl)-1,3,4-oxadiazol-2-thiol (4) was synthesized by the reaction of 3 and CS2 in the presence of KOH. Compound 4 was further converted to the corresponding ester 5 and then 2-(5-((2,4-dimethylphenoxy)methyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazide (6). The final molecules... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acetohydrazides/ Synthesis; Acetohydrazides/Antibacterial activity/ Acetohydrazides/Lipoxygenase/inhibition activity.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300471 |
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