|
|
|
|
|
| HAJIMEHDIPOOR,HOMA; MOSADDEGH,MAHMOUD; NAGHIBI,FARZANEH; HAERI,ALI; HAMZELOO-MOGHADAM,MARYAM. |
| Background and the purpose of the study: The amount of elder people who suffer from Alzheimer disease is continuously increasing every year. Cholinesterase inhibitors have shown to be effective in alleviating the symptoms of the disease, thus opening a field of research for these treatments. Herbal products, owning a reputation as effective agents in many biological studies are now drawing attention for inhibiting acetylcholinesterase, in other words, Alzheimer disease. In the present study, the ability of three sesquiterpene lactones from Inula oculus-christi and I. aucheriana to inhibit AChE has been evaluated through Ellman assay.Materials and Methods: Gaillardin and pulchellin C were obtained from I. oculus-christi and britannin from I. aucheriana by... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acetylcholinesterase inhibitor; Alzheimer; Britannin; Gaillardin; Inula; Pulchellin C. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000200801 |
| |
|
|
| Wang,Zhejian; Ma,Zhao; Wang,Lili; Tang,Chengchen; Hu,Zhibi; Chou,GuiXin; Li,Wankui. |
| Background An endophytic fungus lives within a healthy plant during certain stages of, or throughout, its life cycle. Endophytic fungi do not always cause plant disease, and they include fungi that yield different effects, including mutual benefit, and neutral and pathogenic effects. Endophytic fungi promote plant growth, improve the host plant's resistance to biotic and abiotic stresses, and can produce the same or similar biologically active substances as the host. Thus, endophytic fungal products have important implications in drug development. Result Among the numerous endophytic fungi, we identified two strains, L10Q37 and LQ2F02, that have anti-acetylcholinesterase activity, but the active compound was not huperzine A. The aim of this study was to... |
| Tipo: Journal article |
Palavras-chave: Anti-acetylcholinesterase activity; Acetylcholinesterase inhibitor; Biological characteristics; Endophytic fungi. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000600003 |
| |
|
|
|
