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Risk factors for glucose intolerance in active acromegaly BJMBR
Kreze,A.; Kreze-Spirova,E.; Mikulecky,M..
In the present retrospective study we determined the frequency of glucose intolerance in active untreated acromegaly, and searched for risk factors possibly supporting the emergence of the diabetic condition. Among 43 patients, 8 (19%; 95% CI: 8-33%) had diabetes mellitus and 2 (5%; 1-16%) impaired glucose tolerance. No impaired fasting glycemia was demonstrable. The frequency of diabetes was on average 4.5 times higher than in the general Slovak population. Ten factors suspected to support progression to glucose intolerance were studied by comparing the frequency of glucose intolerance between patients with present and absent risk factors. A family history of diabetes and arterial hypertension proved to have a significant promoting effect (P<0.05,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acromegaly; Diabetes mellitus; Impaired glucose tolerance; Impaired fasting glycemia; Risk factors; Inferential statistics.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001100009
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Expression of E-cadherin, Slug and NCAM and its relationship to tumor invasiveness in patients with acromegaly BJMBR
Mendes,G.A.; Haag,T.; Trott,G.; Rech,C.G.S.L.; Ferreira,N.P.; Oliveira,M.C.; Kohek,M.B.; Pereira-Lima,J.F.S..
Pituitary adenomas account for 10–15% of primary intracranial tumors. Growth hormone (GH)-secreting adenomas account for 13% of all pituitary adenomas and cause acromegaly. These tumors can be aggressive, invade surrounding structures and are highly recurrent. The objective of this study was to evaluate E-cadherin, Slug and neural cell adhesion molecule (NCAM) expression in GH-secreting pituitary adenomas and its relationship to tumor invasiveness. A cross–sectional study of patients who underwent hypophysectomy due to GH-secreting pituitary adenoma from April 2007 to December 2014 was carried out. The medical records were reviewed to collect clinical data. Immediately after surgery, tumor samples were frozen in liquid nitrogen and stored in a biofreezer...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acromegaly; Pituitary neoplasms; Cadherins; Slug; Neural cell adhesion molecules.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200605
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Correlations between forced oscillation technique parameters and pulmonary densitovolumetry values in patients with acromegaly BJMBR
Camilo,G.B.; Carvalho,A.R.S.; Machado,D.C.; Mogami,R.; Kasuki,L.; Gadelha,M.R.; Melo,P.L.; Lopes,A.J..
The aims of this study were to evaluate the forced oscillation technique (FOT) and pulmonary densitovolumetry in acromegalic patients and to examine the correlations between these findings. In this cross-sectional study, 29 non-smoking acromegalic patients and 17 paired controls were subjected to the FOT and quantification of lung volume using multidetector computed tomography (Q-MDCT). Compared with the controls, the acromegalic patients had a higher value for resonance frequency [15.3 (10.9-19.7) vs 11.4 (9.05-17.6) Hz, P=0.023] and a lower value for mean reactance [0.32 (0.21-0.64) vs 0.49 (0.34-0.96) cm H2O/L/s2, P=0.005]. In inspiratory Q-MDCT, the acromegalic patients had higher percentages of total lung volume (TLV) for nonaerated and poorly aerated...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acromegaly; Tomography; Respiratory function tests; Forced oscillation technique.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001000003
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