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| BRUNIERA,FELIPE R.; FERREIRA,FELIPE M.; SAVIOLI,LUIZ R.M.; BACCI,MARCELO R.; FEDER,DAVID; PEREIRA,EDIMAR C.; PEDREIRA,MAVILDE L.G.; PETERLINI,MARIA A.S.; PERAZZO,FÁBIO F.; AZZALIS,LIGIA A.; ROSA,PAULO C.P.; JUNQUEIRA,VIRGINIA B.C.; SATO,MONICA A.; FONSECA,FERNANDO L.A.. |
| Vancomycin (VCM) is indicated in combat against Gram-positive infections, but it is not considered a first-choice drug because of its adverse effects. It is believed that oxidative stress is the primary mechanism of endothelial injury and the consequent VCM toxicity, which varies from phlebitis to nephrotoxicity. Moreover, dose recommendations, dilution, rates and types of infusion are still controversial. The aim of this study was to determine the effect of different VCM dilutions in endothelial, liver and kidney injuries by biochemical parameters and histopathological analysis. Wistar rats were randomly divided into six groups and subjected to femoral vein cannulation for drug administration. Control groups received 0.9 ml of saline and the others... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Vancomycin; Acute kidney injury; Oxidative stress; Hepatotoxicity; Endothelial injury. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401963 |
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| Libório,Alexandre B.; Silva Jr,Geraldo B.; Silva,Carolina G.C.H.; Lima Filho,Francisco J.C.; Studart Neto,Adalberto; Okoba,Willy; Bruin,Veralice M.S. de; Araújo,Sônia M.H.A.; Daher,Elizabeth F.. |
| BACKGROUND: There are no reports on hyponatremia and acute kidney injury (AKI) involved in the course of HIV-related toxoplasmic encephalitis (TE). The main objective of this study was to describe the occurrence of hyponatremia and its relationship with AKI and mortality in HIV-related toxoplasmic encephalitis (TE). METHODS: This was a retrospective cohort study on patients with HIV-related TE. AKI was considered only when the RIFLE (risk, injury, failure, loss, end-stage) criterion was met, after the patient was admitted. RESULTS: A total of 92 patients were included, with a mean age of 36 ± 9 years. Hyponatremia at admission was observed in 43 patients (46.7%), with AKI developing in 25 (27.1%) patients during their hospitalization. Sulfadiazine was the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Toxoplasmosis; Encephalitis; Hyponatremia; Acute kidney injury; HIV; Mortality. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600010 |
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| Corzo-León,Dora Edith; Perales-Martínez,Diana; Martin-Onraet,Alexandra; Rivera-Martínez,Norma; Camacho-Ortiz,Adrian; Villanueva-Lozano,Hiram. |
| ABSTRACT Background: Invasive fungal infections (IFIs) affect >1.5 million people per year. Nevertheless, IFIs are usually neglected and underdiagnosed. IFIs should be considered as a public-health problem and major actions should be taken to tackle them and their associated costs. Aim To report the incidence of IFIs in four Mexican hospitals, to describe the economic cost associated with IFIs therapy and the impact of adverse events such as acute kidney injury (AKI), liver damage (LD), and ICU stay. Methods: This was a retrospective, transversal study carried-out in four Mexican hospitals. All IFIs occurring during 2016 were included. Incidence rates and estimation of antifungal therapy's expenditure for one year were calculated. Adjustments for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fungal infections; Antifungal therapy; Cost; Acute kidney injury; Incidence rate; Mexico. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500360 |
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| Zheng,Guodong; Qu,Hong; Li,Fen; Ma,Weiquan; Yang,Hong. |
| Previous studies have indicated that propofol has immunomodulatory and antioxidative properties. However, the renoprotection effect and the precise mechanisms of propofol in sepsis-induced renal injury remain unclear. The purpose of the present study was to investigate the role of miR-290-5p/CCL-2 signaling in septic mice treatment with propofol. Mice were treated with propofol (50 mg/kg) twice within 24 h. Survival outcome was monitored within 48 h. The mRNA and protein levels were assayed by qRT-PCR and western blotting, respectively. Mouse podocytes (MPC5) were treated with lipopolysaccharide (LPS) to establish the cell model in vitro. The proliferation of MPC5 was monitored using the MTS assay. Cell apoptosis was analyzed by flow cytometry. Propofol... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Propofol; Sepsis; MiR-290-5p; CCL-2; Acute kidney injury. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001100612 |
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| Caires,A.; Fernandes,G.S.; Leme,A.M.; Castino,B.; Pessoa,E.A.; Fernandes,S.M.; Fonseca,C.D.; Vattimo,M.F.; Schor,N.; Borges,F.T.. |
| Cyclosporin-A (CsA) is an immunosuppressant associated with acute kidney injury and chronic kidney disease. Nephrotoxicity associated with CsA involves the increase in afferent and efferent arteriole resistance, decreased renal blood flow (RBF) and glomerular filtration. The aim of this study was to evaluate the effect of Endothelin-1 (ET-1) receptor blockade with bosentan (BOS) and macitentan (MAC) antagonists on altered renal function induced by CsA in normotensive and hypertensive animals. Wistar and genetically hypertensive rats (SHR) were separated into control group, CsA group that received intraperitoneal injections of CsA (40 mg/kg) for 15 days, CsA+BOS and CsA+MAC that received CsA and BOS (5 mg/kg) or MAC (25 mg/kg) by gavage for 15 days. Plasma... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Genetically hypertensive rats; Acute kidney injury; Cyclosporine-A; Bosentan; Macitentan; Endothelin-1. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200611 |
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| Libório,A.B.; Mota,R.M.S.; Abreu,K.L.S.; Silva,A.E.B.; Araújo,S.M.H.A.; Daher,E.F.. |
| The objective of the present study was to evaluate the characteristics of acute kidney injury (AKI) in AIDS patients and the value of RIFLE classification for predicting outcome. The study was conducted on AIDS patients admitted to an infectious diseases hospital inBrazil. The patients with AKI were classified according to the RIFLE classification: R (risk), I (injury), F (failure), L (loss), and E (end-stage renal disease). Univariate and multivariate analyses were used to evaluate the factors associated with AKI. A total of 532 patients with a mean age of 35 ± 8.5 years were included in this study. AKI was observed in 37% of the cases. Patients were classified as "R" (18%), "I" (7.7%) and "F" (11%). Independent risk factors for AKI were thrombocytopenia... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute kidney injury; HIV; AIDS; Prognosis; Mortality; RIFLE. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100013 |
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| Crews,D.C.; Bello,A.K.; Saadi,G.. |
| This article was published in Kidney International volume 95, pages 242–248, https://doi.org/10.1016/j.kint.2018.11.007, Copyright World Kidney Day 2019 Steering Committee (2019) and is reprinted concurrently in several journals. The articles cover identical concepts and wording, but vary in minor stylistic and spelling changes, detail, and length of manuscript in keeping with each journal's style. Any of these versions may be used in citing this article. Note that all authors contributed equally to the conception, preparation, and editing of the manuscript. Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment.... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Acute kidney injury; End stage renal disease; Global health; Health equity; Social determinants of health. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000300101 |
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