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| Silva,F.B.; Romero,W.G.; Carvalho,A.L.R.; Borgo,M.V.; Amorim,M.H.C.; Gouvea,S.A.; Abreu,G.R.. |
| The objective of this study was to evaluate the effect of tamoxifen on the plasma concentration of NT-pro-B-type natriuretic peptide (NT-proBNP) in women undergoing chemotherapy for breast cancer and to correlate changes in NT-proBNP with the left ventricular ejection fraction (LVEF). Over a period of 12 months, we followed 60 women with a diagnosis of breast cancer. The patients were separated into a group that received only chemotherapy (n=23), a group that received chemotherapy + tamoxifen (n=21), and a group that received only tamoxifen (n=16). Plasma levels of NT-proBNP were assessed at 0 (T0), 6 (T6), and 12 (T12) months of treatment, and echocardiography data were assessed at T0 and T12. Plasma NT-proBNP levels were increased in the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cardiovascular risk profile; Adjuvant chemotherapy; Hormone therapy; NT-B-proBNP; Ecocardiography. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000200154 |
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| Figueirêdo,Camila Bezerra Melo; Souza,Joelma Rodrigues de; Soares,Daniel Handerson Galindo; Silva,Caio Cesar de Andrade Rodrigues; Lorena,Virginia Maria Barros de. |
| Non-Hodgkin's lymphoma (NHL) consists of a group of neoplasias involving mainly B cells and represents 90% of all lymphomas. The current available therapy is based on chemotherapy associated with the monoclonal antibody rituximab (Mab Thera(r)), which targets the CD20 protein, present in over 80% of NHL mature B cells. Recent clinical reports show a preference for combining the benefits of immunotherapy and adjuvant chemotherapy, thus generating safe and effective alternative treatments. The current review aimed at evaluating various aspects related to the use of rituximab for NHL, highlighting the possible inhibitory mechanisms of cell proliferation, the achieved clinical results, and the expected clinical and economic outcomes of treatments. The results... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Non-Hodgkin's lymphoma; Antineoplastic combined chemotherapy/protocols; Adjuvant chemotherapy; Rituximab/application/Non-Hodgkin's lymphoma. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300445 |
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