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	Provedor de dados BJMBR (1) Rev. Microbiol. (1) Autor Barbosa,J.A. (1) Barbosa,Joel Antonio (1) Rebello,M.A. (1) Rebello,Moacyr Alcoforado (1) Palavra-chave Aedes albopictus cells (2) Prostaglandin (2) Actinomycin D (1) Heat-shock proteins (1) Mayaro virus (1) Stress proteins (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 1998 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última INHIBITION OF MAYARO VIRUS REPLICATION BY PROSTAGLANDIN A1 IN Aedes albopictus CELLS Rev. Microbiol. Barbosa,Joel Antonio; Rebello,Moacyr Alcoforado. Prostaglandin A1 (PGA1) inhibits Mayaro virus replication in Aedes albopictus cells at nontoxic doses to uninfected cells. At 10 µg/ml, PGA1 decreases virus production by 90%. The presence of PGA1 during virus adsorption, with no treatment after infection, reduces virus yield by 41%. Antiviral activity is observed even when treatment starts at one or two hours post-infection. However, in cells pre-treated with PGA1 during 24 hours, virus replication is not impaired. Thus, events ocurring during initial stages of infection and after virus adsorption and penetration must be the target of PGA1 action. SDS-PAGE analysis of 35S-methionine labelled proteins shows that PGA1 inhibits the synthesis of viral proteins and induces the synthesis of polypeptides with... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mayaro virus; Prostaglandin; Aedes albopictus cells; Heat-shock proteins; Actinomycin D. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141998000300013 Effect of prostaglandin A1 in the induction of stress proteins in Aedes albopictus cells BJMBR Barbosa,J.A.; Rebello,M.A.. Prostaglandins are natural fatty acid derivatives with diverse physiological effects, including immune function and the control of cell growth. While the action of prostaglandins in the induction of stress proteins in vertebrate cells is well documented, their functions in invertebrate cells have been poorly investigated. The purpose of the present study was to investigate the effect of prostaglandin A1 (PGA1; 0.25, 1.25 and 12.5 µg/ml) on protein synthesis during the growth of Aedes albopictus cells. We found that PGA1 stimulates the synthesis of several polypeptides with molecular masses of 87, 80, 70, 57, 29, 27 and 23 kDa in Aedes albopictus cells. When the proteins induced by PGA1 and those induced by heat treatment were compared by polyacrylamide gel... Tipo: Info:eu-repo/semantics/other Palavras-chave: Prostaglandin; Stress proteins; Aedes albopictus cells. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400004 Registros recuperados: 2 Primeira ... 1 ... Última

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