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| Zhang,Xinju; Jin,Lei; Wu,Zhiyuan; Ma,Weizhe; Chen,Yuming; Chen,Gang; Wang,Lixin; Guan,Ming. |
| Abstract The goal of this research was to investigate the linkage disequilibrium between rs9263726 and HLA-B*58:01 in different Chinese ethnic groups (Han, Tibet, and Hui) and to study the feasibility of rs9263726 replacing HLA-B*58:01 as an efficient indicator of potential allopurinol hypersensitivity syndrome. In this study, rs9263726 and HLA-B*58:01 were detected in all samples. For samples of individuals whose rs9263726 genotypes were not consistent with HLA-B*58:01, we did high-resolution typing of HLA-B gene to further confirm the correlation of rs9263726 genotype and special HLA-B alleles. We confirmed that the linkage disequilibrium between rs9263726 and HLA-B*58:01 was more significant in the Han ethnic group (r2=0.886, D’=1.0) than in the Tibet... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rs9263726; HLA-B*58:01; Allopurinol hypersensitivity reaction; Tag SNP. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000400578 |
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