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| MOREIRA,PAULA I; ZHU,XIONGWEI; LIU,QUAN; HONDA,KAZUHIRO; SIEDLAK,SANDRA L; HARRIS,PEGGY L; SMITH,MARK A.; PERRY,GEORGE. |
| Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-β deposition and hyperphosphorylated tau function as compensatory responses and downstream adaptations to ensure that neuronal cells do not succumb to oxidative damage. These findings suggest that Alzheimer disease is associated with a novel balance in oxidant homeostasis. |
| Tipo: Journal article |
Palavras-chave: Alzheimer disease; Antioxidant therapy; Mitochondria; Oxidative stress; Redox metals. |
| Ano: 2006 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100002 |
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| Peng,Tianzhong; Huang,Xuedi; Hu,Suifa; Xie,Gui; Zhou,Cheng; Xiong,Jia; Liu,Rui. |
| ABSTRACT This study aimed to investigate the expression and mechanism of N- methyl -D- aspartate receptor 1 (NMDAR1) in the pathogenesis of Alzheimer disease (AD). Eighty adult Wistar rats were randomly divided into 4 groups (n=20 each) to receive an injection of 0, 5, 7 and 10 μl of 1 μg/μl amyloid-β 42 (Aβ1-42) in the hippocampus. Twenty rats in normal control group were injected with equal volume of saline. After 10 days, the hippocampus was isolated from 5 randomly selected rats in each group. The NMDAR1 protein and mRNA expression was determined by immunohistochemical staining and qRT-PCR. The aquaporin-1 (AQP-1) mRNA expression was also measured by qRT-PCR. We found that both NMDAR1 and AQP-1 expression in Aβ1-42 groups was increased in a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: NMDAR1; Alzheimer disease; Aquaporin; AQP-1. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100435 |
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