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Cardiac evaluation after experimental intoxication by Amorimia rigida (Malpighiaceae) extracts in rabbits J. Venom. Anim. Toxins incl. Trop. Dis.
Borboleta,LR; Silva,EF; Oliveira,MS; Michel,AFRM; Ferraz,VP; Leite,RC; Melo,MM.
Clinical and laboratory changes were evaluated in rabbits after intoxication by Amorimia rigida, a plant that causes sudden death. Nine New Zealand male rabbits, averaging 3.54 kg, were categorized into three groups (n = 3) and received, for eight consecutive days, the equivalent of 30 g/kg dry matter of A. rigida water-soluble (SG) and water-insoluble (IG) extracts via nasoesophageal route. The control group received water. There were no alterations in creatine kinase enzyme (CK), CK myocardial fraction (CKMB) or troponine I (cTnI). None of the animals had clinical or electrocardiographic (conventional and Holter) alterations. There were progressive decreases in the left ventricular ejection fraction and systolic fractional shortening. Doppler...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Toxic plant; Amorimia rigida; Cardiac muscle profile; Electrocardiography; Echocardiography; Rabbit.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000300007
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