|
|
|
| Registros recuperados: 13 | |
|
| |
|
|
| CUNICO,MIRIAM M.; TREBIEN,HERBERT A.; GALETTI,FÁBIO C.; MIGUEL,OBDULIO G.; MIGUEL,MARILIS D.; AUER,CELSO G.; SILVA,CÉLIO L.; SOUZA,ANA OLÍVIA DE. |
| ABSTRACT Ottonia martiana is a plant popularly known in Brazil by the use for toothache. Ethanolic extract (EE), hexane fraction (HF), dichloromethane fraction (DF) and piperovatine obtained from O. martiana were assayed in vitro and in vivo. The acute toxicity of EE was determined, and LD50 values of 164.5 and 65.0 mg/kg by the oral and intraperitoneal routes, respectively, indicated a high toxicity for EE in vivo, explaining its popular use by topical administration only. A local anesthetic-like effect of EE and its fractions was observed in experimental models using pain induction, and such effect involved an analgesic action. The antimycobacterial activity of EE, HF, DF and piperovatine was evaluated against Mycobacterium tuberculosis H37Rv ATCC 27924.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Analgesic; Anesthetic; Antimycobacterial; Ottonia martiana; Piperaceae; Piperovatine. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000501991 |
| |
|
|
| DEL-VECHIO-VIEIRA,GLAUCIEMAR; SANTOS,BRUNA C.S.; ALVES,MARIA SILVANA; ARAÚJO,AÍLSON L.A.; YAMAMOTO,CÉLIA H.; PINTO,MÍRIAM A.O.; KAPLAN,MARIA AUXILIADORA C.; SOUSA,ORLANDO V.. |
| ABSTRACT The present study was designed to investigate the antioxidant, antinociceptive and anti-inflammatory activities of the ethanol extract from Ageratum fastigiatum branches. Phytochemical screening and total phenol and flavonoid contents were determined. The antioxidant activity was assessed by 2,2-diphenyl-1-pycrilhydrazin (DPPH) and iron reducing power methods. The antinociceptive effect was evaluated using the acetic acid-induced writhing, formalin, hot plate and tail immersion assays; while the carrageenan-induced paw edema and pleurisy tests were performed to examine the anti-inflammatory activity against acute inflammation. The extract revealed the presence of flavonoids, tannins, coumarins, terpenes, sterols and saponins. Expressive levels of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ageratum fastigiatum; Analgesic; Anti-inflammatory; Antioxidant; Flavonoids; Total phenols. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401471 |
| |
|
|
| Raju,Golam Sarwar; Moghal,Md Mizanur Rahman; Hossain,Mohammad Salim; Hassan,Md Mahadi; Billah,Md Mustahsan; Ahamed,Sayed Koushik; Rana,SM Masud. |
| BACKGROUND: The current study aims at evaluating the analgesic, anti-pyretic and anti-inflammatory properties of methanolic extract of the stem, bark and leaves of Launaea sarmentosa and Aegialitis rotundifolia roxb. RESULTS: The AELS and AEAR extract presented a significant (***p < 0.001) dose dependent increase in reaction time in writhing method and showed inhibition of 63.1% and 57.1% respectively at the doses of 400 mg/kg body weight while standard drug showed (P < 0.001) inhibition of 69.23%. In tail immersion method, AELS and AEAR showed maximum time of tail retention at 30 min in hot water i.e. 6.93 sec and 6.54 sec respectively at highest doses of 400 mg/kg body weight than lower dose while standard pentazocine showed reaction time of 7.62... |
| Tipo: Journal article |
Palavras-chave: Launaea sarmentosa; Aegialitis rotundifolia roxb; Analgesic; Antipyretic; Anti-inflammatory. |
| Ano: 2014 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100049 |
| |
|
|
| Bhowmick,Rumpa; Sarwa,Md Shahid; Dewan,Syed Masudur Rahman; Das,Abhijit; Das,Binayok; Uddin,Mir Muhammad Nasir; Islam,Md Siddiqul; Islam,Mohammad Safiqul. |
| BACKGROUND: The study was conducted to evaluate the in vitro thrombolytic activity, and in vivo analgesic, anti-inflammatory and antipyretic potentials of different hydrocarbon soluble extracts of Litsea glutinosaleaves for the first time widely used in the folkloric treatments in Bangladesh. This work aimed to create new insights on the fundamental mechanisms of the plant extracts involved in these activities. RESULTS: In thrombolytic activity assay, a significant clot disruption was observed at dose of 1 mg/mL for each of the extracts (volume 100 μL) when compared to the standard drug streptokinase. The n-hexane, ethyl acetate, chloroform, and crude methanolic extracts showed 32.23 ± 0.26, 37.67 ± 1.31,... |
| Tipo: Journal article |
Palavras-chave: Acetic acid induced writhing; Analgesic; Anti-inflammatory; Antipyretic; Litsea glutinosa; Thrombolytic. |
| Ano: 2014 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100050 |
| |
|
| |
|
| |
|
|
| Abdon,A.P.V.; Leal-Cardoso,J.H.; Coelho-de-Souza,A.N.; Morais,S.M.; Santos,C.F.. |
| Croton nepetaefolius Baill., is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. In the present study the antinociceptive effects of the essential oil of C. nepetaefolius (EOCn), administered orally, were evaluated in male Swiss mice (20-25 g). In the acetic acid-induced writhing test, EOCn (100 and 300 mg/kg; N = 14 and N = 12, respectively) was effective at the highest dose. In the hot-plate test, EOCn at 30 and 300 mg/kg, but not at 3 mg/kg, significantly increased the latency at all observation times up to the 180th min (N = 12 for each dose). In the formalin test, EOCn significantly reduced paw licking in the second phase of the test at 100 mg/kg (N =... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Croton nepetaefolius; Essential oil; Analgesic; Antinociception; Formalin test; Hot-plate test. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000015 |
| |
|
| |
|
|
| Rašković,Aleksandar Lazar; Kvrgić,Maja Petar; Tomas,Ana Drago; Stilinović,Nebojša Petar; Čabarkapa,Velibor Spasoje; Stojšić-Milosavljević,Anastazija Ðurica; Kusturica,Milica Nada Paut; Rakić,Dušica Branko. |
| The plant world represents an important source of potential therapeutic agents, but concomitant administration of herbal and conventional medications may result in interactions with subsequent beneficial or adverse effects. This study was designed to examine the analgesic effect of thyme tincture and thyme syrup, two commonly used thyme formulations, and their interactions with codeine, paracetamol, pentobarbital and diazepam in mice. The identification and quantification of thymol and carvacrol were carried out by GC/MS and GC/FID. The analgesic activity was studied using a hot plate method. Effects of thyme syrup on diazepam-induced motor coordination impairment in rotarod test and on pentobarbital-induced sleeping time were also determined. Thymol... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Thymus vulgaris; Hot plate; Analgesic; Interactions; Pentobarbital; Diazepam. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100634 |
| |
|
|
| El-Sharkawy,Karam Ahmed; AlBratty,Mohammed Mofreh; Alhazmi,Hassan Ahmad. |
| Pyrimidine derivative 3 was afforded through the reaction of compound (1) with 5-ureidohydantion (2). Product 3 underwent a cyclization to produce fused pyrimidine derivative 7, although the latter product 7 was synthesized through one step via the reaction of compound (1) with 5-ureidohydantion (2) using another catalyst. Compound 3 was oriented to react with cyclic ketones 8a,b in the presence of elemental sulfur, salicylaldehyde (10), aryldiazonium chlorides 12a,b and ω-bromo-4-methoxy- acetophenone (14), which afforded, fused thiophene derivatives 9a,b, coumarin derivative 11, arylhdrazono derivatives 13a,b and 4-methoxyphenyl butenyl derivative 15, respectively. The latter product 15 was reacted with either potassium cyanide (16a) or potassium... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pyrimidine derivative; Thiophene; Coumarin; Pyridine; Pyrrole; Analgesic; Antipyretic and anti-inflammatory agents. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400603 |
| |
|
|
| Ruiz,Thaís; Peres,Thalita Priscila da Silva; Campos,Wilma Neres da Silva; Sorte,Eveline da Cruz Boa; Ribeiro,Alexandre Pinto. |
| This study aimed to evaluate the effects of tramadol on tear production, intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs. Dogs were randomly assigned to receive 4mg kg-1 (n=11) and 6mg kg-1 (n=11) of tramadol hydrochloride intramuscularly. Tear production (Schirmer tear test, STT-1), IOP (applanation tonometry) and the PD (electronic pachymetry) were assessed before, 30 and 60 minutes after administration of tramadol. Data were compared by analysis of variance for repeated measures (P<0.05). Parameters evaluated before, at 30 and 60min, in dogs treated with 4 and 6mg kg-1, were respectively: (STT-1) 22.50±3.38, 21.14±3.94 and 21.09±2.99mm min-1; and 23.05±3.73,22.64±3.76 and 22.82±3.25mm min-1. (IOP) 18.14±2.68, 17.68±2.59 and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Opioid; Analgesic; Miosis; Keratoconjunctivitis sicca. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015000400724 |
| |
|
|
| Martínez Hormaza,Ioanna; Victoria Amador,María del Carmen; Brito Álvarez,Gisselle; Morón Rodríguez,Francisco; López Barreiro,Marisol; García Hernández,Ana Ibis; Duménigo González,Abel; Morejón Rodríguez,Zulema; Bacallao Elguea,Yunier; Nossin,Emmanuel. |
| Introduction: leave decoction of Cordia martinicensis (Jacq.) Roem. & Schult. is commonly used in Dominica, Martinique and St. Lucia to relieve thoracic pain and fever. Objectives: to validate the antiinflammatory, antinociceptive (analgesic), and antipyretic ethnobotanical uses of Cordia martinicensis in experimental animal models. Methods: 30 % aqueous extract of Cordia martinicensis dry leaves was prepared just before use. Analgesic activity was assayed by writhing and tail flick, and antiinflammatory activity by the ear oedema test, both in mice. Finally, antipyretic activity was tested by inducing pyrexia with brewer's yeast in rats. Results: decoction of Cordia martinicensis significantly decreased the number of abdominal stretchings by 44.4... |
| Tipo: Journal article |
Palavras-chave: Cordia martinicensis; Analgesic; Antiinflammatory; Antipyretic. |
| Ano: 2014 |
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962014000100005 |
| |
| Registros recuperados: 13 | |
|
|
|
