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	Provedor de dados BJMBR (1) BJM (1) Autor Clementi,M.E. (1) Facciotti,Maria Cândida Reginato (1) Giardina,B. (1) Inoue,Olavo Ossamu (1) Misiti,F. (1) Mordente,A. (1) Padilla,Gabriel (1) Schmidell Netto,Willibaldo (1) Mais... Palavra-chave Anthracyclines (2) Aglycone metabolite (1) Carbon catabolite repression (1) Doxorubicin (1) Doxorubicinol (1) Hemoglobin (1) Pentose phosphate pathway (1) Streptomyces (1) [13C]-NMR spectroscopy (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2007 (1) 2003 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The secondary alcohol and aglycone metabolites of doxorubicin alter metabolism of human erythrocytes BJMBR Misiti,F.; Giardina,B.; Mordente,A.; Clementi,M.E.. Anthracyclines, a class of antitumor drugs widely used for the treatment of solid and hematological malignancies, cause a cumulative dose-dependent cardiac toxicity whose biochemical basis is unclear. Recent studies of the role of the metabolites of anthracyclines, i.e., the alcohol metabolite doxorubicinol and aglycone metabolites, have suggested new hypotheses about the mechanisms of anthracycline cardiotoxicity. In the present study, human red blood cells were used as a cell model. Exposure (1 h at 37ºC) of intact human red blood cells to doxorubicinol (40 µM) and to aglycone derivatives of doxorubicin (40 µM) induced, compared with untreated red cells: i) a ~2-fold stimulation of the pentose phosphate pathway (PPP) and ii) a marked inhibition of the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Anthracyclines; Doxorubicinol; Doxorubicin; Aglycone metabolite; Pentose phosphate pathway; [13C]-NMR spectroscopy; Hemoglobin. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200005 Carbon catabolite repression of retamycin production by Streptomyces olindensis ICB20 BJM Inoue,Olavo Ossamu; Schmidell Netto,Willibaldo; Padilla,Gabriel; Facciotti,Maria Cândida Reginato. Retamycin is an anthracyclinic antitumoral complex produced by Streptomyces olindensis ICB20. In this work the influence of different glucose concentrations in the feed medium on the production of retamycin was studied. Chemostat cultures employing glucose concentration varying between 10 g/L and 25 g/L showed that use of high glucose concentration resulted in catabolite repression of the biosynthesis of the antitumoral. The highest specific retamycin production rate, qRTM = 7.8 mg/g.h, was obtained when glucose concentration was 10 g/L. The lowest value of qRTM, 2.5 mg/g.h, was observed when glucose concentration was 20 and 25 g/L. The residual glucose concentration varied from 0 to 13 g/L, as the glucose concentration in the feed was increased from 10 to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Streptomyces; Anthracyclines; Carbon catabolite repression. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000100012 Registros recuperados: 2 Primeira ... 1 ... Última

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