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Antimicrobial activity of honeys from two stingless honeybee species and Apis mellifera (Hymenoptera: Apidae) against pathogenic microorganisms Acta Amazonica
Cruz,Carolinie Batista Nobre da; Pieri,Fabio Alessandro; Carvalho-Zilse,Gislene Almeida; Orlandi,Patrícia Puccinelli; Nunes-Silva,Carlos Gustavo; Leomil,Luciana.
Honeys are described possessing different properties including antimicrobial. Many studies have presented this activity of honeys produced by Apis mellifera bees, however studies including activities of stingless bees honeys are scarce. The aim of this study was to compare the antimicrobial activity of honeys collected in the Amazonas State from Melipona compressipes, Melipona seminigra and Apis mellifera against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Chromobacterium violaceum, and Candida albicans. Minimum inhibitory concentrations were determined using the agar dilution method with Müller-Hinton agar (for bacteria) or Saboraud agar (for yeast). Staphylococcus aureus and E. faecalis were inhibited by all honeys at concentrations...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Melipona; Antibacterial; Antifungal; Natural products; Functional food.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672014000200015
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Antimicrobial activity of bergenin from Endopleura uchi (Huber) Cuatrec Acta Amazonica
Silva,Saulo L. da; Oliveira,Viviane Guedes de; Yano,Tomomasa; Nunomura,Rita de Cássia Saraiva.
Endopleura uchi (Huber) Cuatrec. is an Amazon species traditionally used as treatment for inflammations and female disorders. Bergenin was isolated from ethyl acetate fraction of bark of E. uchi by using column chromatography over sephadex LH-20 and then silica gel 60 flash. Its structure was identified on the basis of its NMR spectra. The antimicrobial activity of bergenin and fractions of methanol extract of E. uchi were evaluated against ATCC microorganisms (Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, Candida albicans, C. guilliermondii, Aspergillus flavus, A. nidulans). Clinically isolated strains of all of these microorganisms, along with C. tropicalis, A. niger, Shigella sonnei,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibacterial; Antifungal; Candida; Humiriaceae; Uxi-amarelo.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672009000100019
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Evaluation of in vitro biological properties of Senna occidentalis (L.) Link Biological Sciences
Lombardo, Márcia; Kiyota, Sumika; Kato, Edna Tomiko Miyake; Mathor, Monica Beatriz; Pinto, Terezinha de Jesus Andreoli; Kaneko, Telma Mary.
Senna species have been widely used by American, African and Indian ethic groups mainly in the treatment of feebleness, constipation, liver disorders and skin infections. Senna occidentalis (L.) Link is a perennial shrub native to South America and indigenous to tropical regions throughout the world. Current study evaluated the antimicrobial activity of aqueous and hydroalcoholic extracts from S. occidentalis prepared from different parts of the plant. Antimicrobial activity was assessed against standard pharmaceutical microorganisms by spectrophotometry and microdilution technique. Escherichia coli was sensitive only to compounds extracted from seeds which may be proteinaceous. A broader antimicrobial spectrum was demonstrated by the hydroalcoholic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 2.10.06.00-8 Cassia occidentalis; Leguminosae; Traditional medicine; Antibacterial; Antifungal; Fibroblasts Etnofarmacologia.
Ano: 2015 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/22525
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Antibacterial activity of Lamiaceae plant extracts in clinical isolates of multidrug-resistant bacteria Anais da ABC (AABC)
ASSIS,FELIPE V. DE; SIQUEIRA,FLÁVIA L.; GONÇALVES,ISABELA E.; LACERDA,RAFAEL P.; NASCIMENTO,RAFAELA A.; ARAÚJO,STHÉFANE G.; ANDRADE,JÉSSICA T.; HERRERA,KARINA M.S.; LIMA,LUCIANA A.R.S.; FERREIRA,JAQUELINE M.S..
ABSTRACT The antibacterial activity of plant extracts of the Lamiaceae family was evaluated against clinical isolates of multi-resistant Gram-negative bacteria by broth microdilution technique. Promising results were obtained considering that all extracts were active for at least two bacterial species with MIC ranging from 0.5 to 2.0 mg/mL.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibacterial; Clinical isolates; Lamiaceae extracts; Multidrug-resistant.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000401665
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A comparative study of phytoconstituents and antibacterial activity of in vitro derived materials of four Passiflora species Anais da ABC (AABC)
J. SIMÃO,MARIELA; J.S. BARBOZA,THIAGO; G. VIANNA,MARCELA; GARCIA,RENATA; MANSUR,ELISABETH; P.R. IGNACIO,ANA CLAUDIA; PACHECO,GEORGIA.
Abstract Passiflora species are well known for their common use in popular medicine for the treatment of several diseases, such as insomnia, anxiety, and hysteria, in addition to their anti-inflammatory, antioxidant, analgesic and antibacterial potential. However, few data about the chemical composition and the medicinal potential of in vitro derived materials are available. Therefore, the goal of this work was to compare, for the first time, the phytoconstituents of in vitro derived materials of four Passiflora species, and evaluate the antibacterial potential of their extracts against 20 Gram-positive and negative strains. Chromatographic analysis indicated the presence of saponins in roots extracts from all studied species, whereas leaf extracts...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibacterial; Chromatography; Flavonoids; Passiflora; Saponins.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000602805
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Melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities Anais da ABC (AABC)
SANTOS,TÁSSIA L.A. DOS; QUEIROZ,RAPHAEL F.; SAWAYA,ALEXANDRA C.H.F.; LOPEZ,BEGOÑA GIMENEZ-CASSINA; SOARES,MILENA B.P.; BEZERRA,DANIEL P.; RODRIGUES,ANA CAROLINA B.C.; PAULA,VANDERLÚCIA F. DE; WALDSCHMIDT,ANA MARIA.
ABSTRACT Geopropolis is a special type of propolis produced by stingless bees. Several pharmacological properties have been described for different types of geopropolis, but there have been no previous studies of the geopropolis from Melipona mondury. In this study, we investigated the antioxidant, antibacterial, and antiproliferative activities of M. mondury geopropolis, and determined its chemical profile. The antioxidant activity was determined using in vitro ABTS·+, ·DPPH, and β-carotene/linoleic acid co-oxidation methods. The antibacterial activity was determined using a microdilution method with Pseudomonas aeruginosa, Staphylococcus aureus, and methicillin-resistant S. aureus. The antiproliferative effect was determined in tumor cell lines using the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibacterial; Antioxidant; Antiproliferative; Geopropolis; Melipona mondury.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000502247
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Antibacterial and cytotoxicity activities and phytochemical analysis of three ornamental plants grown in Mexico Anais da ABC (AABC)
RÍOS-CHÁVEZ,PATRICIA; PEREZ-GONZALEZ,JORDY; SALGADO-GARCIGLIA,RAFAEL; RAMÍREZ-CHÁVEZ,ENRIQUE; MOLINA-TORRES,JORGE; MARTINEZ-TRUJILLO,MIGUEL; CARREON-ABUD,YAZMIN.
Abstract: This study evaluates the antibacterial, cytotoxic activities, and phytochemical composition, of Callistemon citrinus, Hibiscus rosa-sinensis and Plumbago auriculata leaves and flowers, three ornamental plants in Mexico. However, in other countries offers a range of other uses. Ethanol extracts of C. citrinus leaf and flower presented stronger antibacterial activity than the extracts obtained from the other two plants. C. citrinus leaf showed low cytotoxicity (LC50 <600 µg/mL) on the brine shrimp test, whereas the ethanol extracts of H. rosa-sinensis and P. auriculata leaves showed no cytotoxic activity. Flower extracts obtained from the three plants did no exhibit cytotoxicity. GC-MS analysis revealed that the ethanol extract of P. auriculata...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibacterial; Artemia salina; Callistemon citrinus; Cytotoxic; Lupeol.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300611
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Cytotoxicity and bacterial membrane destabilization induced by Annona squamosa L. extracts Anais da ABC (AABC)
PINTO,NÍCOLAS C.C.; SILVA,JUCÉLIA B.; MENEGATI,LAURA M.; GUEDES,MARIA CLARA M.R.; MARQUES,LUCAS B.; SILVA,THIAGO P. DA; MELO,ROSSANA C.N. DE; SOUZA-FAGUNDES,ELAINE M. DE; SALVADOR,MARCOS J.; SCIO,ELITA; FABRI,RODRIGO L..
ABSTRACT This study aimed to further investigate the cytotoxicity against tumor cell lines and several bacterial strains of Annona squamosa and its mode of action. Methanol extracts of A. squamosa leaves (ASL) and seeds (ASS) were used. ASL showed significant antibacterial activity against S. aureus, K. pneumoniae and E. faecalis with MIC values of 78, 78 and 39 µg/mL respectively. Moreover, ASL exhibited significant biofilm disruption, rapid time dependent kinetics of bacterial killing, increased membrane permeability and significantly reduced the cell numbers and viability. Regarding the cytotoxicity against tumor cell lines, ASS was more active against Jurkat and MCF-7 cells, with CI50 1.1 and 2.1 µg/mL, respectively. ASL showed promising activity...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Alkaloids; Annona squamosa; Antibacterial; Citotoxicity; Herbal medicine.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000502053
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Antimicrobial profile screening of two oils of Copaifera genus Arq. Bras. Med. Vet. Zootec.
Pieri,F.A.; Silva,V.O.; Souza,C.F.; Costa,J.C.M.; Santos,L.F.; Moreira,M.A.S..
O objetivo deste estudo foi identificar a atividade inibitória de óleos de copaíba sobre o crescimento dos micro-organismos: Shigella flexneri, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Citrobacter freundi, Staphylococcus aureus, Actinobacillus pleuropneumoniae e Haemophilus parasuis. Foi realizado um teste de difusão em ágar com duas soluções a 10% de óleos de copaíba obtidos de duas diferentes espécies de copaíba (Copaifera officinalis e C. langsdorffii) e um controle negativo com tween 80 e água. Os isolados clínicos de H. parasuis e A. pleuropneumoniae foram incubados em microaerofilia. Os resultados mostraram três espécies Gram-negativas inibidas por ambas as soluções de óleo de copaíba: E. coli, P. aeruginosa...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phytotherapics; Antimicrobial; Antibacterial; Copaifera.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000100037
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Antioxidant, Antibacterial activity and Brine shrimp toxicity test of some Mountainous Lichens from Nepal Biol. Res.
Paudel,Babita; Datta Bhattarai,Hari; Prasad Pandey,Durga; Seoun Hur,Jae; Gyu Hong,Soon; Kim,Il-Chan; Han Yim,Joung.
A total of twenty four lichen species belonging to six families were collected from mountainous region of Nepal. The methanol extracts of each species were tested for antimicrobial and antioxidant activitiesin vitro. It was found that extracts of twenty one lichen species were active againstB. subtilis and seven species were active againstS. aureus. Similarly, in DPPH assay, three speciesPeltigera sp.,Cladonia sp., andCanoparmelia sp. showed comparable activity with commercial standard, BHA. In ABTS+ assay, extracts ofParmoterma sp.,Ramalina sp.,Peltigera sp. andCladonia sp. showed stronger activity than ascorbic acid. The observed data after comparison with previously published reports indicated that the high altitude lichens contain stronger antioxidant...
Tipo: Journal article Palavras-chave: Antibacterial; Antioxidant; Nepal lichens; Free radicals.
Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400010
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Evaluation of cytotoxicity and biological activities in extracellular polysaccharides released by cyanobacterium Arthrospira platensis BABT
Challouf,Rafika; Trabelsi,Lamia; Ben Dhieb,Rym; El Abed,Omeya; Yahia,Ali; Ghozzi,Khamissa; Ben Ammar,Jihen; Omran,Hela; Ben Ouada,Hatem.
The aim of this work was to evaluate the cytotoxicity of Arthrospira platensis Extracellular Polymeric Substances (EPS) for colon cancer and kidney cell lines. Results showed that EPS were free from cytotoxic effects. A variety of solvents were assessed for their ability to extract the bioactive ingredients from EPS. Methanol gave the highest yield (75.75%) than other solvents. The extracts were tested for activities against a collection of Gram+/- bacteria. The methanol extract exhibited a more potent activity than the other organic extracts, whereas the aqueous extract was active against Staphylococcus epidermis (Gram+) and Salmonella typhimurium (Gram-). Finally, The extracts were also tested for the antioxidant activity, using the Trolox Equivalent...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cyanobacteria; Exoplysaccharides; Cytotoxicity; Antibacterial; Antioxidant; Activity.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000400024
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Comparative evaluation of anthelmintic and antibacterial activities in leaves and fruits of Garcinia cambogia (Gaertn.) desr. and Garcinia indica (Dupetit-Thouars) choisy BABT
Tharachand,C.; Selvaraj,C. Immanuel; Abraham,Z..
This study aimed to evaluate the in vitro anthelmintic activity and antibacterial activity of the extracts from the leaves and fruits of Garcinia indica (Dupetit-Thouars) Choisy and Garcinia cambogia(Gaertn.) Desr. using the Indian earthworm Pheretima posthuma. Two concentrations (25 and 50 mg/mL) of various extracts such as petroleum ether, chloroform, ethyl acetate, methanol and water were tested. Albendazole at the concentrations of 25 and 50 mg/mL was used as the standard reference. Significant anthelmintic effects of the fruits and leaves of G. cambogia and G. indica (P<0.05) were observed and the results were expressed in terms of paralysis and death time. All the extracts showed the dose dependent paralysis and death of earthworms. Among all the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anthelmintic; Antibacterial; Garcinia cambogia; Garcinia indica; Minimal Inhibitory Concentration.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000300379
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Modulation of drug resistance and biofilm formation of Staphylococcus aureus isolated from the oral cavity of Tunisian children BJID
Zmantar,Tarek; Ben Slama,Rihab; Fdhila,Kais; Kouidhi,Bochra; Bakhrouf,Amina; Chaieb,Kamel.
Abstract Objectives: This study aims to investigate the antimicrobial and the anti-biofilm activities of Lactobacillus plantarum extract (LPE) against a panel of oral Staphylococcus aureus (n = 9) and S. aureus ATCC 25923. The in vitro ability of LPE to modulate bacterial resistance to tetracycline, benzalchonium chloride, and chlorhexidine were tested also. Methods: The minimum inhibitory concentrations (MICs) and the minimal bactericidal concentrations of Lactobacillus plantarum extract, tetracycline, benzalchonium chloride and clohrhexidine were determined in absence and in presence of a sub-MIC doses of LPE (1/2 MIC). In addition, the LPE potential to inhibit biofilm formation was assessed by microtiter plate and atomic force microscopy assays....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibacterial; Staphylococcus aureus; Biofilm; Antibiotics; Synergetic; Lactobacillus.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100027
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In-vitro antimicrobial activity of Psidium guajava l. leaf extracts against clinically important pathogenic microbial strains BJM
Nair,Rathish; Chanda,Sumitra.
The methanol, acetone and N, N-dimethylformamide (DMF) fractions of leaves of Psidium guajava L. were evaluated for antibacterial and antifungal activity. Piperacillin and gentamicin were used as standards for antibacterial assay, while nystatin and flucanazole were used as standards for antifungal assay. 91 clinically important strains were used for the study which were both clinical isolates as well as identified strains. The antibacterial activity was more pronounced against gram-positive bacterial and fungal strains. Moderate activity was shown against the gram-negative bacterial strains studied.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibacterial; Antifungal; Psidium guajava extracts; Clinical isolates.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000300013
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Antimicrobial activity of some medicinal plants from the cerrado of the central-western region of Brazil BJM
Violante,Ivana Maria Póvoa; Hamerski,Lidilhone; Garcez,Walmir Silva; Batista,Ana Lucia; Chang,Marilene Rodrigues; Pott,Vali Joana; Garcez,Fernanda Rodrigues.
Ethanol extracts from six selected species from the Cerrado of the Central-Western region of Brazil, which are used in traditional medicine for the treatment of infectious diseases and other medical conditions, namely Erythroxylum suberosum St. Hil. (Erythroxylaceae), Hyptis crenata Pohl. ex Benth. (Lamiaceae), Roupala brasiliensis Klotz. (Proteaceae), Simarouba versicolor St. Hil. (Simaroubaceae), Guazuma ulmifolia Lam. (Sterculiaceae) and Protium heptaphyllum (Aubl.) March. (Burseraceae), as well as fractions resulting from partition of these crude extracts, were screened in vitro for their antifungal and antibacterial properties. The antimicrobial activities were assessed by the broth microdilution assay against six control fungal strains, Candida...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antifungal; Antibacterial; Antimicrobial; Artemia salina; Cerrado.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000400009
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Volatile compounds of Lamiaceae exhibit a synergistic antibacterial activity with streptomycin BJM
Araújo,Sthéfane G.; Alves,Lucas F.; Pinto,Maria Eduarda A.; Oliveira,Graziela T.; Siqueira,Ezequias P.; Ribeiro,Rosy I. M. A.; Ferreira,Jaqueline M. S.; Lima,Luciana A. R. S..
Bacterial infections cause thousands of deaths in the world every year. In most cases, infections are more serious because the patient is already weakened, and often, the bacteria are already resistant to the antibiotics used. Counterparting this negative scenario, the interest in medicinal plants as an alternative to the synthetic antimicrobial drugs is blossoming worldwide. In the present work, we identified the volatile compounds of ethanol extracts of Melissa officinalis, Mentha sp., Ocimum basilicum, Plectranthus barbatus, and Rosmarinus officinalis by gas chromatography/mass spectrometry (GC/MS). Also was evaluated antimicrobial activity of ethanol extracts against 6 bacteria of clinical interest, and was tested the interaction of these extracts with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lamiaceae; Antibacterial; Ethanol extracts; Volatile compounds; Streptomycin.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000400026
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Removal and killing of multispecies endodontic biofilms by N-acetylcysteine BJM
Choi,Young-Suk; Kim,Cheul; Moon,Ji-Hoi; Lee,Jin-Yong.
ABSTRACT Removal of bacterial biofilm from the root canal system is essential for the management of endodontic disease. Here we evaluated the antibacterial effect of N-acetylcysteine (NAC), a potent antioxidant and mucolytic agent, against mature multispecies endodontic biofilms consisting of Actinomyces naeslundii, Lactobacillus salivarius, Streptococcus mutans and Enterococcus faecalis on sterile human dentin blocks. The biofilms were exposed to NAC (25, 50 and 100 mg/mL), saturated calcium hydroxide or 2% chlorhexidine solution for 7 days, then examined by scanning electron microscopy. The biofilm viability was measured by viable cell counts and ATP-bioluminescence assay. NAC showed greater efficacy in biofilm cell removal and killing than the other...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibacterial; Biofilm removal; Multispecies endodontic biofilm; N-acetylcysteine; Root canal medicament.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000100184
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Chemical composition, phytotoxic potential, biological activities and antioxidant properties of Myrcia hatschbachii D. Legrand essential oil BJPS
Gatto,Larissa Junqueira; Fabri,Natasha Tiemi; Souza,Angela Maria de; Fonseca,Natasha Stopinski Triaquim da; Furusho,Alethéia dos Santos; Miguel,Obdulio Gomes; Dias,Josiane de Fatima Gaspari; Zanin,Sandra Maria Warumby; Miguel,Marilis Dallarmi.
Myrcia hatschbachii D. Legrand (Myrtaceae) is a native and endemic species from Brazil. This study investigated the essential oil composition, phytotoxic potential, in vitro toxicity, antioxidant properties and antibacterial activity of species. Chromatographic analysis of essential oil identified trans-calamanene, (E)-caryophyllene and spathulenol as major components. Antioxidant capacity was determined by the DPPH• scavenging method and phosphomolybdenum complex formation assay. Antibacterial activity was evaluated using the Minimal Inhibitory Concentration test, demonstrating that the essential oil was active toward Enterococcus faecalis and Staphylococcus aureus. Phytotoxic activity of essential oil was analyzed by testing interference on germination...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Essential oil; Phytotoxic; Antioxidant; Antibacterial; Hemolysis; Artemia salina.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100560
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Characterization of bacterial endophytes from Myanmar medicinal plants for antimicrobial activity against human and plant pathogens BJPS
Myo,Ei Mon; Maung,Chaw Ei Htwe; Mya,Khin Mar; Khai,Aye Aye.
This research aimed to investigate the antagonistic activity of the bacterial endophytes from Myanmar medicinal plants. Thirty-one bacterial isolates were isolated from Myanmar medicinal plants: Tinospora cordifolia (Wild.) Miers., Catharanthus roseus G. Don., Tectona hamiltoniana Wall. and Boscia variabilis Collett & Hemsl. (Capparaceae). Dual culture and agar well diffusion methods were used for antimicrobial assay. One endophyte from Catharanthus roseus and two bacterial isolates from Boscia variabilis Collett & Hemsl. (Capparaceae) had not only the antibacterial activity towards the human pathogenic bacteria but also the antifungal activity against the plant pathogenic fungi. From 16S rRNA sequencing, one strain from Catharanthus roseus G. Don....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibacterial; Antifungal; Culture conditions; Endophytes; Medicinal plants.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100513
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Enzyme inhibition and antibacterial potential of 4-Hydroxycoumarin derivatives BJPS
Saleem,Afia; Bukhari,Syed Majid; Zaidi,Asma; Farooq,Umar; Ali,Majid; Khan,Asma; Khan,Sidra; Shah,Kausar Hussain; Mahmood,Adeem; Khan,Farhan Ahmed.
The 4-Hydroxycoumarin derivatives are known to show a broad spectrum of pharmacological applications. In this paper we are reporting the synthesis of a new series of 4-Hydroxycoumarin derivatives synthesized through Knovenegal condensation; they were characterized by using UV-Vis, FT-IR, NMR spectroscopies. The synthesized compounds were evaluated for antibacterial activity against Staphylococcus aureus and Salmonella typhimurium strains. The compounds (2), (3) and (8) showed favorable antibacterial activity with zone of inhibitions 26.5± 0.84, 26.0 ± 0.56 and 26.0 ± 0.26 against Staphylococcus aureus (Gram-positive) respectively. However, the compounds (5) and (9) were found more active with 19.5 ± 0.59 and 19.5 ± 0.32 zone of inhibitions against...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 4-Hydroxycoumarin; Anti-urease; Carbonic anhydrase; Aldehydes; Antibacterial.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100580
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