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Registros recuperados: 11
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Antifungal susceptibilities of Cryptococcus species complex isolates from AIDS and non-AIDS patients in Southeast China BJID
Li,Meng; Liao,Yong; Chen,Min; Pan,Weihua; Weng,Lixing.
Cryptococcus spp. are common causes of mycoses in immunocompromised patients. To determine the drug susceptibilities of clinical Cryptococcus spp. isolates, the characteristics of 61 clinical Cryptococcus spp. complex isolates and their antifungal susceptibilities were investigated, including 52 C. neoformans and 9 C. gattii isolates collected at Shanghai between 1993 and 2009. Antifungal susceptibility of clinical isolates to amphotericin B, fluconazole, itraconazole, and flucytosine were determined by the microdilution method M27-A2 and the ATB FUNGUS 3 kit. The 90% minimum inhibitory concentration (MIC90) and susceptibility ranges were as follows: 1 (0.0625-1) µg/mL for amphotericin B, 4 (0.125-16) µg/ mL for fluconazole, 0.25 (0.0313-4) µg/mL for...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cryptococcus neoformans; Cryptococcus gattii; Antifungal agents.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200012
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Antifungal pharmacodynamics: Latin America's perspective BJID
Gonzalez,Javier M.; Rodriguez,Carlos A.; Agudelo,Maria; Zuluaga,Andres F.; Vesga,Omar.
Abstract The current increment of invasive fungal infections and the availability of new broad-spectrum antifungal agents has increased the use of these agents by non-expert practitioners, without an impact on mortality. To improve efficacy while minimizing prescription errors and to reduce the high monetary cost to the health systems, the principles of pharmacokinetics (PK) and pharmacodynamics (PD) are necessary. A systematic review of the PD of antifungals agents was performed aiming at the practicing physician without expertise in this field. The initial section of this review focuses on the general concepts of antimicrobial PD. In vitro studies, fungal susceptibility and antifungal serum concentrations are related with different doses and dosing...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antifungal agents; Pharmacology; Pharmacodynamics; Pharmacokinetics; Candidiasis; Aspergillosis.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100079
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Vulvovaginal candidiasis in Mato Grosso, Brazil: pregnancy status, causative species and drugs tests BJM
Dias,Luciana Basili; Melhem,Márcia de Souza Carvalho; Szeszs,Maria Walderez; Meirelles Filho,José; Hahn,Rosane Christine.
Causative agent in majority of VVC is Candida albicans, but infection due to non-C. albicans is common. Use of empiric antifungal therapy in Brazil due to syndromic management of vulvovaginitis could act as risk factor for increase resistance among VVC causative agents. From Mato Grosso patients, 160 with culture-proved among 404 women who had clinical symptoms of VVC, were enrolled in this study. 70 non-pregnant women and 90 pregnant women were included. Candida albicans was the most prevalent, representing 72.9% in the non-pregnant group and 92.3% in the pregnant group. Differences in species distribution were noted between the two groups, being C. parapsilosis the second more prevalent species among non-pregnant women. Susceptibility testing revealed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Vulvovaginal candidiasis; Antifungal susceptibility testing; Antifungal agents; Candida albicans.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000400009
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Susceptibility variation of Malassezia pachydermatis to antifungal agents according to isolate source BJM
Weiler,Caroline Borges; Jesus,Francielli Pantella Kunz de; Nardi,Graziela Habib; Loreto,Érico Silva; Santurio,Janio Morais; Coutinho,Selene Dall'Acqua; Alves,Sydney Hartz.
Malassezia pachydermatisis associated with dermatomycoses and otomycosis in dogs and cats. This study compared the susceptibility of M. pachydermatis isolates from sick (G1) and healthy (G2) animals to azole and polyene antifungals using the M27-A3 protocol. Isolates from G1 animals were less sensitive to amphotericin B, nystatin, fluconazole, clotrimazole and miconazole.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Malassezia pachydermatis; Susceptibility; Antifungal agents.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000100026
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Susceptibility to heat and antifungal agents of Cryptococcus neoformans var. neoformans (serotype D) isolated from Eucalyptus spp in Rio Grande do Sul, Brazil BJM
Horta,Jorge A; Faganello,Josiane; Rosa e Silva,Lívia K; Oliveira,Loiva T; Santurio,Jânio M; Vainstein,Marilene H; Alves,Sydney Hartz.
In this work we studied the susceptibility to heat and antifungal agents of the first strains of environmental Cryptococcus neoformans var neoformans (serotype D) isolated in the state of Rio Grande do Sul, Brazil. In order to achieve a rigorous analysis, we employed the methodology recommended by NCCLS, Yeast Nitrogen Base (YNB) proposed by Ghannoum et al (YNB-1), Antibiotic medium 3 (AM3) indicated by others, YNB adjusted to the NCCLS methodology (YNB-2) and Etest. Our results indicate that all strains were susceptible to amphotericin B (0.0625-0.5 µg/mL), fluconazole (0.125-8.0 µg/mL), itraconazole (0.031-0.25 µg/mL) and flucytosine (0.125-4.0 µg/mL). The C. neoformans serotype D strains were more susceptible to heat (47ºC/30 min) than C. neoformans...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cryptococcus neoformans; Heat susceptibility; Antifungal agents.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822005000100001
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Different culture media applied to the study of Cryptococcus neoformans susceptibility to amphotericin B and fluconazole BJM
Alves,Sydney Hartz; Oliveira,Loiva T.; Goulart,Letícia S.; Linares,Carlos Eduardo B.; Griebeler,Josiane; Santurio,Janio M..
This study compared the performance of three culture media used for the determination of minimal inhibitory concentration (MIC) of amphotericin B and fluconazole against 48 Cryptococcus neoformans strains. For amphotericin B the media employed were RPMI 1640 medium, as indicated by NCCLS as reference, Yeast Nitrogen Base (YNB) as proposed by Ghannoum et al. (YNB-1), Antibiotic medium 3 (AM3) indicated by others, and YNB as proposed by us (YNB-2). In YNB-1, amphotericin B showed broader MIC ranges, varying from 0.125 µg/ml to 1.0 µg/ml; in RPMI 1640 medium and YNB-2 the MICs were similar and in AM3 the MIC ranges were narrower. The same pattern was observed for MIC 90%. For fluconazole the media employed were RPMI 1640 and YNB-1. The MIC ranges were broader...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cryptococcus neoformans; Susceptibility; Antifungal agents.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000100005
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Antifungal suscepitibility profile of candida spp. oral isolates obtained from denture wearers BJM
Lyon,J.P.; Moreira,L.M.; Cardoso,M.A.G.; Saade,J.; Resende,M.A..
Denture stomatitis is an inflammatory condition that occurs in denture wearers and is frequently associated with Candida yeasts. Antifungal susceptibility profiles have been extensively evaluated for candidiasis patients or immunosupressed individuals, but not for healthy Candida carriers. In the present study, fluconazole, itraconazole, voriconazole, terbinafine and 5-flucytosin were tested against 109 oral Candida spp. isolates. All antifungal agents were effective against the samples tested except for terbinafine. This work might provide epidemiological information about Candida spp. drug susceptibility in oral healthy individuals.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Denture wearers; Candida carriage; Normal oral mucosa; Antifungal agents.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000400013
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Candida dubliniensis in a Brazilian family with an HIV 1- infected child: identification, antifungal susceptibility, drug accumulation and sterol composition BJM
Melo,Nadja Rodrigues de; Taguchi,Hideaki; Culhari,Vitoria V.P.; Sano,Ayako; Fukushima,Kazutaka; Miyaji,Makoto; Manning,Nigel; Kelly,Steven L.; Vilela,Marluce S..
This study investigated the prevalence of C. dubliniensis in a Brazilian family with an HIV - infected child. A total of 42 oral isolates were obtained from eight family members. The identification of C. dubliniensis was performed by polymerase chain reactions (PCR) using primers against a specific sequence of the C. dubliniensis cytochrome b gene. Only the HIV-infected child and his grandmother were colonized by C. dubliniensis. In this study C. dubliniensis isolated from the HIV-infected child exhibited high susceptibility for azoles tested with MICs of 0.125 and 0.5 µg/mL for voriconazole and fluconazole, respectively. Accumulation of [³H] fluconazole in C. dubliniensis isolated from the HIV-infected child was slightly reduced in comparison to the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Candida dubliniensis; Antifungal agents; Sterol composition.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822006000300008
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Use of the VITEK 2 system to identify and test the antifungal susceptibility of clinically relevant yeast species BJM
Melhem,MSC; Bertoletti,A; Lucca,HRL; Silva,RBO; Meneghin,FA; Szeszs,MW.
Eleven quality control isolates (Candida albicans ATCC 64548, C. tropicalis ATCC 200956, C. glabrata ATCC 90030, C. lusitaniae ATCC 200951, C. parapsilosis ATCC 22019, C. krusei ATCC 6258, C. dubliniensis ATCC 6330, Saccharomyces cerevisiae ATCC 9763, Cryptococcus neoformans ATCC 90012, C. gattii FIOCRUZ-CPF 60, and Trichosporon mucoides ATCC 204094) and 32 bloodstream isolates, including C. albicans, C. tropicalis, C. parapsilosis, C. glabrata, C. krusei, C. guilliermondii, C. pelliculosa (Pichia anomala), C. haemulonii, C. lusitaniae, and C. kefyr were identified at the species level by the VITEK 2 system. A set of clinical isolates (32 total) were used as challenge strains to evaluate the ability of the VITEK 2 system to determine the antifungal...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antifungal agents; Candida; Susceptibility testing methods; MIC; CLSI; EUCAST.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000400033
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Mutants with heteroresistance to amphotericin B and fluconazole in Candida BJM
Claudino,A.L.R.; Peixoto Junior,R.F.; Melhem,M.S.C.; Szeszs,M.W.; Lyon,J.P.; Chavasco,J.K.; Franco,M.C..
Several studies have reported the occurrence of infections caused by Candida yeasts as well as the increasing prevalence of non albicans species. The aim of the present work is focused on the obtaining of heteroresistance to amphotericin B and fluconazole in Candida species using two distinct methodologies: selection and induction. Resistant samples were obtained by selective pressure using a medium with fluconazole for growth, followed by growth in a medium with amphotericin B. The selective pressure was also created beginning with growth in amphotericin B medium followed by growth in fluconazole medium. Concomitantly, samples were submitted to the induction of resistance through cultivation in increasing concentrations of fluconazole, followed by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amphotericin B; Antifungal agents; Candida spp.; Fluconazole; Heteroresistance; Resistant mutants.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000400028
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In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedis BJM
Soares,Maria Magali Stelato Rocha; Cury,Arlete Emily.
The in vitro activity of antifungal and antiseptic agents were evaluated against dermatophytes isolated from patients with tinea pedis. The antifungals studied were: ciclopirox olamine, cetoconazole, tolciclate and terbinafine, and the antiseptics were: povidine iodine (PVPI), propolis, Fungol®, Andriodermol®, and boric acid. The minimum inhibitory concentration (MIC) or the minimal dilution concentration (MDC) was determined by an agar dilution method using modified yeast nitrogen agar base, and the minimum fungicidal concentration (MFC) or minimum fungicidal dilution (MFD) was determined with subcultures on Sabouraud dextrose agar. All drugs studied were active against the dermatophytes at lower concentrations than those used in products and/or...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dermatophytes; Antifungal agents; Antiseptic agents; Susceptibility testing; Tinea pedis.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822001000200012
Registros recuperados: 11
Primeira ... 1 ... Última
 

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