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Characterization of Antimycins – Producing Streptomycete Strain VY46 Isolated from Slovak Soil BABT
Charousová,Ivana; Steinmetz,Heinrich; Medo,Juraj; Javoreková,Sona; Wink,Joachim.
ABSTRACT The strain no. VY46 was isolated from agricultural soil of Slovak republic and tested for potential antimicrobial activity against various human pathogens. On the basis of results, strain VY46 significantly inhibited growth of yeast Candida albicans and therefore was used for further characterization. In order to explore the potential bioactivities, extract of the fermented broth culture was prepared with organic solvent extraction method. The ethylacetate extract was subjected to HPLC fractionation against Candida albicans and followed by LC/MS analysis for potential production of anticandidal substances. The analysis resulted in the identification of two antimycins antibiotics, which may be responsible for important anticandidal activity of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Streptomycetes; Anticandidal activity; Metabolite production; Antimycins antibiotics.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100349
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