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	Provedor de dados BJMBR (3) BABT (1) Autor Flatschart,R.B. (1) Gallo,M. (1) Iribarren,A.M. (1) Montserrat,J.M. (1) Phillips,M.I. (1) Sogayar,M.C. (1) Wiebe,Leonard I. (1) Mais... Palavra-chave Antisense (4) Ribozymes (2) Aptamer (1) Aptamers (1) Expression interference (1) Gene function (1) Gene therapy (1) Genetic knock-out (1) Hypertension (1) Modified nucleotides (1) Molecular biology (1) Molecular imaging (1) Nucleic acids (1) Nucleosides (1) Nucleotides (1) Oligonucleotide libraries (1) Oligonucleotides (1) PET (1) SELEX method (1) Spiegelmer (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2007 (1) 2003 (1) 2000 (1) 1999 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Applications of nucleoside-based molecular probes for the in vivo assessment of tumour biochemistry using positron emission tomography (PET) BABT Wiebe,Leonard I.. Positron emission tomography (PET) is a non-invasive nuclear imaging technique. In PET, radiolabelled molecules decay by positron emission. The gamma rays resulting from positron annihilation are detected in coincidence and mapped to produce three dimensional images of radiotracer distribution in the body. Molecular imaging with PET refers to the use of positron-emitting biomolecules that are highly specific substrates for target enzymes, transport proteins or receptor proteins. Molecular imaging with PET produces spatial and temporal maps of the target-related processes. Molecular imaging is an important analytical tool in diagnostic medical imaging, therapy monitoring and the development of new drugs. Molecular imaging has its roots in molecular biology.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Molecular biology; Molecular imaging; PET; Nucleosides; Nucleotides; Nucleic acids; Oligonucleotides; Antisense; Aptamer; Spiegelmer. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000300011 Functional analysis of newly discovered growth control genes: experimental approaches BJMBR Flatschart,R.B.; Sogayar,M.C.. A large number of DNA sequences corresponding to human and animal transcripts have been filed in data banks, as cDNAs or ESTs (expression sequence tags). However, the actual function of their corresponding gene products is still largely unknown. Several of these genes may play a role in regulation of important biological processes such as cell division, differentiation, malignant transformation and oncogenesis. Elucidation of gene function is based on 2 main approaches, namely, overexpression and expression interference, which respectively mimick or suppress a given phenotype. The currently available tools and experimental approaches to gene functional analysis and the most recent advances in mass cDNA screening by functional analysis are discussed. Tipo: Info:eu-repo/semantics/article Palavras-chave: Gene function; Transgene overexpression; Expression interference; Antisense; Ribozymes; Transgenic cells and animals; Genetic knock-out. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700011 Design and applications of modified oligonucleotides BJMBR Gallo,M.; Montserrat,J.M.; Iribarren,A.M.. Oligonucleotides have a wide range of applications in fields such as biotechnology, molecular biology, diagnosis and therapy. However, the spectrum of uses can be broadened by introducing chemical modifications into their structures. The most prolific field in the search for new oligonucleotide analogs is the antisense strategy, where chemical modifications confer appropriate characteristics such as hybridization, resistance to nucleases, cellular uptake, selectivity and, basically, good pharmacokinetic and pharmacodynamic properties. Combinatorial technology is another research area where oligonucleotides and their analogs are extensively employed. Aptamers, new catalytic ribozymes and deoxyribozymes are RNA or DNA molecules individualized from a randomly... Tipo: Info:eu-repo/semantics/article Palavras-chave: Modified nucleotides; Antisense; Ribozymes; Oligonucleotide libraries; Aptamers; SELEX method. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000200001 Somatic gene therapy for hypertension BJMBR Phillips,M.I.. Gene therapy for hypertension is needed for the next generation of antihypertensive drugs. Current drugs, although effective, have poor compliance, are expensive and short-lasting (hours or one day). Gene therapy offers a way to produce long-lasting antihypertensive effects (weeks, months or years). We are currently using two strategies: a) antisense oligodeoxynucleotides (AS-ODN) and b) antisense DNA delivered in viral vectors to inhibit genes associated with vasoconstrictive properties. It is not necessary to know all the genes involved in hypertension, since many years of experience with drugs show which genes need to be controlled. AS-ODN are short, single-stranded DNA that can be injected in naked form or in liposomes. AS-ODN, targeted to angiotensin... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gene therapy; Hypertension; Antisense; Vectors. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600013 Registros recuperados: 4 Primeira ... 1 ... Última

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