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Consecuencias de la contaminación por hidrocarburos del petróleo sobre la salud humana y fertilidad de suelos en Huimanguillo, Tabasco. Colegio de Postgraduados
Vázquez Luna, Dinora.
En México, el desarrollo basado en la industria petrolera ha afectado los suelos y recursos naturales del sureste del país; sin embargo, no hay estudios que vinculen sus efectos sobre el desarrollo equitativo de los habitantes en zonas contaminadas. Por ello, el objetivo del trabajo fue analizar desde la perspectiva de género, los efectos sociales sobre el desarrollo equitativo de las familias, en cuatro zonas de los ejidos de Humanguillo, Tabasco (Rovirosa, El Paraíso, La Ceiba y Gurría), que se ubican a una distancia de 0.5, 2.5, 7 y 12 kilómetros al sur la petroquímica La Venta. Se realizaron encuestas con enfoque de género y de salud, donde las unidades de análisis fueron las familias. Se realizaron análisis de suelos para determinar los efectos de la...
Palavras-chave: Género; Asma; Contaminación ambiental; Hidrocarburos; Alergias; Gender; Asthma; Environmental pollution; Hydrocarbons; Allergies; Doctorado; Desarrollo Rural.
Ano: 2011 URL: http://hdl.handle.net/10521/422
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Consecuencias de la contaminación por hidrocarburos del petróleo sobre la salud humana y fertilidad de suelos en Huimanguillo, Tabasco. Colegio de Postgraduados
Vázquez Luna, Dinora.
En México, el desarrollo basado en la industria petrolera ha afectado los suelos y recursos naturales del sureste del país; sin embargo, no hay estudios que vinculen sus efectos sobre el desarrollo equitativo de los habitantes en zonas contaminadas. Por ello, el objetivo del trabajo fue analizar desde la perspectiva de género, los efectos sociales sobre el desarrollo equitativo de las familias, en cuatro zonas de los ejidos de Humanguillo, Tabasco (Rovirosa, El Paraíso, La Ceiba y Gurría), que se ubican a una distancia de 0.5, 2.5, 7 y 12 kilómetros al sur la petroquímica La Venta. Se realizaron encuestas con enfoque de género y de salud, donde las unidades de análisis fueron las familias. Se realizaron análisis de suelos para determinar los efectos de la...
Palavras-chave: Género; Asma; Contaminación ambiental; Hidrocarburos; Alergias; Gender; Asthma; Environmental pollution; Hydrocarbons; Allergies; Doctorado; Desarrollo Rural.
Ano: 2011 URL: http://hdl.handle.net/10521/422
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Investigating the Effect of the Homeopathic Immunomodulator, MODUL8® on Blood Count, Bronchial Lavage and Fibrin Ultrastructure on Experimental Asthmatic BALB/c Mice International Journal of Morphology
Oberholzer,Hester Magdalena; Vieira,Warren Antonio; Pretorius,Etheresia.
Modul8® is a composite mixture of natural products that are known to be an immunomodulator. In the current study the effect of this immunomodulator is tested on an experimental asthmatic BALB/c mouse model to investigate its properties on the white blood cell count in the blood and bronchial lavage of the animals since white blood cells play a fundamental role in the inflammatory process involved in asthma. As it is known that platelets also play an important role in the immune system, the ultrastructure of platelets and fibrin networks were also investigated by scanning electron microscopy. The animals were sensitised, nebulized and treated over a period of 43 days until termination. Results from the blood smears as well as the bronchial lavage smears...
Tipo: Journal article Palavras-chave: Modul8®; Asthma; BALB/c mouse model; White blood cells; Fibrin and platelet ultrastructure.
Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300049
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Respiratory function in healthy first-degree relatives of asmathic adolescents JBAG
Pereira,C; Veiga,N; Barros,H.
Asthma is a complex disease associated with biological and physiological phenotypes. The objective of this study was to compare the respiratory function in healthy first-degree relatives of asthmatic and non-asthmatic adolescents. We used a cross-sectional approach to assess 101 family cases (presence of one or more adolescents classified as asthmatic) and 275 stable families (families without adolescents classified as asthmatic). We obtained a final sample of 822 relatives. The respiratory function was evaluated by the forced expiratory volume in 1 second (FEV), and the forced vital capacity (FVC), using the Microlab 3300® Spirometer. A self-administered questionnaire was used to record upper and lower airway symptoms, allergic symptoms and medical...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Respiratory function; Genetic factors; Environmental factors; Phenotype.
Ano: 2013 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332013000300003
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Estimation of Treatment Effect of Asthma Case Management Using Propensity Score Methods AgEcon
Brandt, Sylvia J.; Gale, Sara; Tager, Ira.
Objective: To estimate the treatment effect from participating in an asthma intervention that was part of the National Asthma Control Program. Study Setting: Data on children who participated in asthma case management (N=270) and eligible children who did not participate in case management (N=2,742) were extracted from a claims database. Study Design: We created 81 measures of health care utilization and 40 measures of neighborhood characteristics that could be related to participation in the program. The participation model was selected using the cross-validation-based Deletion Substitution and Addition (DSA) algorithm. We used optimal full matching for the vector of Mahalanobis’ distances and propensity scores to estimate the difference between...
Tipo: Working or Discussion Paper Palavras-chave: Asthma; Treatment effect; Health intervention; Propensity scores; Consumer/Household Economics; Health Economics and Policy; Research Methods/ Statistical Methods; I1; D13; H51; C31; C80; C81; C83.
Ano: 2009 URL: http://purl.umn.edu/53124
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EFFECT OF CLIMATE THERAPY AND REHABILITATION IN MÁTRA MEDICAL INSTITUTE AgEcon
Muller, Anetta; Kerenyi, Erika; Konyves, Erika.
Our research we organised at the Mátra Medical Institute in Mátraháza and Kékestetô among sick of asthma, COPD and hayfever. Our aim was to prove the effect of climate therapy in the Mátra Medical Institute. The subalpine climate plays a very important role in the cure of the Respiratory diseases, because to improve the life quality of the sick and reduce the medicine uses after the therapy. Our research took part more than 100 respiratory diseased. We analyse the data with SPSS.version 16. We measure average, standard deviation, Chi² probe, t-probe. You can see our results in the article.
Tipo: Journal Article Palavras-chave: Asthma; Pulmonology illnesses; Climate therapy; Life-quality; Marketing.
Ano: 2011 URL: http://purl.umn.edu/104664
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Asthma Management Survey of Participants in an Inner City Asthma Intervention AgEcon
Sadof, Matthew; Brandt, Sylvia J..
Background: The Inner City Asthma Intervention (ICAI) was a national multi-center implementation of an evidence-based intervention to reduce asthma morbidity. Objective: This study describes mitigating behaviors and reported outcomes in families with asthma who completed the intervention and a post-intervention survey at one of the ICAI sites. Results: Eighty percent (0.72- 0.88, 95% confidence interval) of these families made five or more changes to mitigate exposure to environmental asthma triggers. The majority of families (0.84-0.96, 95% confidence interval) reported an improved awareness of asthma symptoms and less school absences, limitations of activity, unplanned doctor visits, and asthma related sleep disruption.
Tipo: Working or Discussion Paper Palavras-chave: Asthma; Health intervention; Health behavior; Health Economics and Policy; I12; I18; Z13.
Ano: 2007 URL: http://purl.umn.edu/14526
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Nanoparticle-based therapy for respiratory diseases Anais da ABC (AABC)
SILVA,ADRIANA L. DA; SANTOS,RAQUEL S.; XISTO,DÉBORA G.; ALONSO,SILVIA DEL V.; MORALES,MARCELO M.; ROCCO,PATRICIA R.M..
Nanotechnology is an emerging science with the potential to create new materials and strategies involving manipulation of matter at the nanometer scale (<100 nm). With size-dependent properties, nanoparticles have introduced a new paradigm in pharmacotherapy – the possibility of cell-targeted drug delivery with minimal systemic side effects and toxicity. The present review provides a summary of published findings, especially regarding to nanoparticle formulations for lung diseases. The available data have shown some benefits with nanoparticle-based therapy in the development of the disease and lung remodeling in respiratory diseases. However, there is a wide gap between the concepts of nanomedicine and the published experimental data and clinical...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Turberculosis; Nanotechnology; Lung cancer.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100137
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Genetic polymorphisms and asthma: findings from a case - control study in the Madeira island population Biol. Res.
Berenguer,Anabela Gonçalves; Fernandes,Ana Teresa; Oliveira,Susana; Rodrigues,Mariana; Ornelas,Pedro; Romeira,Diogo; Serrão,Tânia; Rosa,Alexandra; Câmara,Rita.
BACKGROUND: Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Global Initiative for Asthma (GINA) guidelines, established their sensitization profile, and measured their forced expiratory volume in 1second (FEV1) and forced vital capacity (FVC) indexes. Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33),...
Tipo: Journal article Palavras-chave: Asthma; Madeira; SNPs; Susceptibility; Severity.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100040
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Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model Biol. Res.
Hwan-Hee,Jang; Su-Yeon,Cho; Mi-Ju,Kim; Jung-Bong,Kim; Sung-Hyen,Lee; Mee-Young,Lee; Young-Min,Lee.
BACKGROUND: Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflammatory response were investigated RESULTS: Salvia plebeia R. Br. inhibited production of pro-inflammatory cytokines, such as TNF-&#945; and IL-6, as well as nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. NO and pro-inflammatory cytokine production was suppressed more effectively by SE of the aerial parts (SE-A) than of the roots (SE-R) of S. plebeia. In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. We also investigated the antiasthmatic effects of SE in an...
Tipo: Journal article Palavras-chave: Anti-inflammatory; Asthma; Salvia plebeia.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100041
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Stem cells and respiratory diseases BABT
Abreu,Soraia Carvalho; Maron-Gutierrez,Tatiana; Garcia,Cristiane Sousa Nascimento Baez; Morales,Marcelo Marcos; Rocco,Patricia Rieken Macedo.
Stem cells have a multitude of clinical implications in the lung. This article is a critical review that includes clinical and experimental studies of MedLine and SciElo database in the last 10 years, where we highlight the effects of stem cell therapy in acute respiratory distress syndrome or more chronic disorders such as lung fibrosis and emphysema. Although, many studies have shown the beneficial effects of stem cells in lung development, repair and remodeling; some important questions need to be answered to better understand the mechanisms that control cell division and differentiation, therefore enabling the use of cell therapy in human respiratory diseases.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bone marrow; Fibrosis; Repair; Acute respiratory distress syndrome; Asthma; Emphysema.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700005
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Mesenchymal Stromal Cells Modulate PAF-stimulated Equine Alveolar Macrophages BABT
Michelotto,Pedro Vicente; Bastos,Fernanda Zettel; Barussi,Fernanda Cristina Mendes; Senegaglia,Alexandra Cristina; Nishiyama,Anita.
Abstract Platelet-activating factor (PAF) is a potent proinflammatory mediator that is produced in increased amounts in the lungs of asthmatic humans and horses. The present pilot study, shows that mesenchymal stromal cells can modulate alveolar macrophage function in asthma, interfering in the activity of PAF, being another potential pathway for mesenchymal stromal cells benefits in asthma.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Horses; Lung; Platelet-activating factor; Pulmonary inflammation.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100306
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Sildenafil decreases rat tracheal hyperresponsiveness to carbachol and changes canonical transient receptor potential gene expression after antigen challenge BJMBR
Sousa,C.T.; Brito,T.S.; Lima,F.J.B.; Siqueira,R.J.B.; Magalhães,P.J.C.; Lima,A.A.M.; Santos,A.A.; Havt,A..
Inhibition of type-5 phosphodiesterase by sildenafil decreases capacitative Ca2+ entry mediated by transient receptor potential proteins (TRPs) in the pulmonary artery. These families of channels, especially the canonical TRP (TRPC) subfamily, may be involved in the development of bronchial hyperresponsiveness, a hallmark of asthma. In the present study, we evaluated i) the effects of sildenafil on tracheal rings of rats subjected to antigen challenge, ii) whether the extent of TRPC gene expression may be modified by antigen challenge, and iii) whether inhibition of type-5 phosphodiesterase (PDE5) may alter TRPC gene expression after antigen challenge. Sildenafil (0.1 µM to 0.6 mM) fully relaxed carbachol-induced contractions in isolated tracheal rings...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Ovalbumin; Capacitative Ca2+ entry; Transient receptor potential proteins.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000600010
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Early prediction of poor outcome in patients with acute asthma in the emergency room BJMBR
Mallmann,F.; Fernandes,A.K.; Ávila,E.M.; Nogueira,F.L.; Steinhorst,A.M.P.; Saucedo,D.Z.; Machado,F.J.; Raymundi,M.G.; Dalcin,P.T.R.; Menna Barreto,S.S..
Early identification of patients who need hospitalization or patients who should be discharged would be helpful for the management of acute asthma in the emergency room. The objective of the present study was to examine the clinical and pulmonary functional measures used during the first hour of assessment of acute asthma in the emergency room in order to predict the outcome. We evaluated 88 patients. The inclusion criteria were age between 12 and 55 years, forced expiratory volume in the first second below 50% of predicted value, and no history of chronic disease or pregnancy. After baseline evaluation, all patients were treated with 2.5 mg albuterol delivered by nebulization every 20 min in the first hour and 60 mg of intravenous methylprednisolone....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Outcome; Index; Prognosis; Emergency medicine.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100006
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Asthma: where is it going? BJMBR
Faffe,D.S..
Asthma is characterized by reversible airway obstruction, airway hyperresponsiveness, and airway inflammation. Although our understanding of its pathophysiological mechanisms continues to evolve, the relative contributions of airway hyperresponsiveness and inflammation are still debated. The first mechanism identified as important for asthma was bronchial hyperresponsiveness. In a second step, asthma was recognized also as an inflammatory disease, with chronic inflammation inducing structural changes or remodeling. However, persistence of airway dysfunction despite inflammatory control is observed in chronic severe asthma of both adults and children. More recently, a potential role for epithelial-mesenchymal communication or transition is emerging, with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Epithelial-mesenchymal unit; Bronchial hyperresponsiveness; Remodeling.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000900001
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Vitamin D3 levels and NLRP3 expression in murine models of obese asthma: association with asthma outcomes BJMBR
Zhang,J-H.; Chen,Y-P.; Yang,X.; Li,C-Q..
Vitamin D (25(OH)D3) is an essential nutrient that plays a role in the immune system. Serum 25(OH)D3 is found to be associated with asthma. However, the role of vitamin D in obese asthma remains unclear. Therefore, we investigated the association between vitamin D levels and asthma outcomes in a murine model of obese asthma. We also evaluated NLRP3 inflammasome activity in the pathogenesis of obese asthma. We divided 20 male Balb/c mice (3–4 weeks old) into 4 groups: normal control, asthma, obese, and obese asthma and developed an obese asthma mouse model. Airway hyperreactivity, cytokine concentrations, 25(OH)D3 levels, NLRP3 mRNA and IL-1β mRNA expressions were measured. Lung histology and bronchoalveolar lavage fluid (BALF) cell count were also...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Obesity; Airway hyperreactivity; NLRP3 inflammasome; Vitamin D3.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100612
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Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection BJMBR
Gaspar-Sobrinho,F.P.; Souza-Machado,A.; Santos,S.B.; Orge,G.; Lessa,H.A.; Cruz,A.A.; Carvalho,E.M..
Human T-cell lymphotropic virus type 1 (HTLV-1) induces an exacerbated type 1 immune response characterized by high spontaneous IFN-γ and TNF-α production. Allergic rhinitis and asthma are associated with the type 2 immune response, with elevated secretion of IL-4 and IL-5. The aim of this study was to characterize the immune response in atopic HTLV-1 carriers. The cytokine profile of atopic HTLV-1 carriers (N = 10; all females) was compared with that of non-atopic HTLV-1 carriers (N = 14; 9 females and 5 males). Mean patient age of atopic and non-atopic groups was 45 ± 8 and 38 ± 11 years, respectively. All atopic HTLV-1 carriers had rhinitis with or without asthma and a skin prick test positive for Dermatophagoides pteronyssinus antigen 1 (Derp-1). There...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Atopy; Cytokines; HTLV-1; Rhinitis.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200005
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Gastroesophageal reflux episodes in asthmatic patients and their temporal relation with sleep architecture BJMBR
Mello-Fujita,L.; Roizenblat,S.; Frison.,C.R.; Rodrigues Junior,L.; Garbuio,S.; Tufik,S.; Bittencourt,L.R.A..
Gastroesophageal reflux (GER) is common in asthma patients and can contribute to sleep disruption. The aim of the present study was to determine the time-related distribution of GER events together with their impact on sleep in asthmatic subjects with GER disease symptoms. The inclusion criteria were: 18-65 years, controlled moderate to severe asthma and GER-compatible clinical evidence. The exclusion criteria were: chronic obstructive lung disease, smoking, infections of the upper airways, use of oral corticosteroids, other co-morbidities, pregnancy, sleep-related disorders, night-time shift work, and the use of substances with impact on sleep. Asthmatic patients with nocturnal symptoms were excluded. All-night polysomnography and esophageal pH monitoring...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Gastroesophageal reflux; Polysomnography; Sleep.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200012
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Association between ADAM metallopeptidase domain 33 gene polymorphism and risk of childhood asthma: a meta-analysis BJMBR
Sun,F.J.; Zou,L.Y.; Tong,D.M.; Lu,X.Y.; Li,J.; Deng,C.B..
This study aimed to investigate the association between ADAM metallopeptidase domain 33 (ADAM33) gene polymorphisms and the risk of childhood asthma. The relevant studies about the relationship between ADAM33 gene polymorphisms and childhood asthma were searched from electronic databases and the deadline of retrieval was May 2016. The single nucleotide polymorphisms (SNPs) of ADAM33 (rs511898, rs2280092, rs3918396, rs528557, rs2853209, rs44707, rs2280091 and rs2280089) were analyzed based on several models including the allele, codominant, recessive and dominant models. The results showed that the ADAM33 rs2280091 polymorphism in all four genetic models was associated with an increased risk of childhood asthma. Positive associations were also found between...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Childhood; Asthma; ADAM33; Gene polymorphisms; Asthma risk; Meta-analysis.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001000609
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Effect of asthma severity on symptom perception in childhood asthma BJMBR
Cabral,A.L.B.; Conceição,G.M.; Saldiva,P.H.N.; Martins,M.A..
Individual ability to perceive airway obstruction varies substantially. The factors influencing the perception of asthma are probably numerous and not well established in children. The present study was designed to examine the influence of asthma severity, use of preventive medication, age and gender on the association between respiratory symptoms (RS) and peak expiratory flow (PEF) rates in asthmatic children. We followed 92 asthmatic children, aged 6 to 16 years, for five months. Symptom scores were recorded daily and PEF was measured twice a day. The correlations among variables at the within-person level over time were analyzed for each child and for the pooled data by multivariate analysis. After pooling the data, there was a significant (P<0.05)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Asthma severity; Pulmonary function tests; Symptom perception; Childhood asthma.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000300006
Registros recuperados: 37
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