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	Provedor de dados BJMBR (1) BJPS (1) Autor Alves,Naiane Ferraz Bandeira (1) Auler Jr.,J.O.C. (1) Carmona,M.J.C. (1) Malbouisson,L.M.S. (1) Pereira,V.A. (1) Porpino,Suênia Karla Pacheco (1) Santos,S.R.C.J. (1) Silva,Alexandre Sérgio (1) Mais... Palavra-chave Atenolol (2) Beta-blockers/negative chronotropic effect (1) Cardiopulmonary bypass (1) Coronary artery bypass grafting surgery (1) Hypertension (1) Pharmacokinetics (1) Physical exercise (1) Propanolol (1) Propranolol (1) Training heart rate/control (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2009 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effect of cardiopulmonary bypass on the pharmacokinetics of propranolol and atenolol BJMBR Carmona,M.J.C.; Pereira,V.A.; Malbouisson,L.M.S.; Auler Jr.,J.O.C.; Santos,S.R.C.J.. The pharmacokinetics of some β-blockers are altered by cardiopulmonary bypass (CPB). The objective of this study was to compare the effect of coronary artery bypass graft (CABG) surgery employing CPB on the pharmacokinetics of propranolol and atenolol. We studied patients receiving oral propranolol with doses ranging from 80 to 240 mg (N = 11) or atenolol with doses ranging from 25 to 100 mg (N = 8) in the pre- and postoperative period of CABG with moderately hypothermic CPB (32°C). On the day before and on the first day after surgery, blood samples were collected before β-blocker administration and every 2 h thereafter. Plasma levels were determined using high-performance liquid chromatography and data were treated by pharmacokinetics-modelling.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Propranolol; Atenolol; Pharmacokinetics; Coronary artery bypass grafting surgery; Cardiopulmonary bypass. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600016 The period between beta-blocker use and physical activity changes training heart rate behavior BJPS Alves,Naiane Ferraz Bandeira; Porpino,Suênia Karla Pacheco; Silva,Alexandre Sérgio. The Brazilian Society of Cardiology (SBC) proposes that hypertensive subjects who use beta-blockers and practice physical exercises must have their training heart rate (HR) corrected due to the negative chronotropic effect of this drug. Nevertheless, if the physical activity is performed outside of plasmatic half-life, correction may not be necessary. This study investigated the exercise chronotropic response both inside and outside the beta-blocker plasmatic half-life. Nine subjects in use of atenolol or propranolol, and six controls, carried out three walking sessions in three days according to different schedules: EX2 (two hours after drug administration, at the plasmatic peak); EX11 (eleven hours after drug administration, at the end of plasmatic... Tipo: Info:eu-repo/semantics/article Palavras-chave: Beta-blockers/negative chronotropic effect; Atenolol; Propanolol; Hypertension; Physical exercise; Training heart rate/control. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400017 Registros recuperados: 2 Primeira ... 1 ... Última

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