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| Beaudet,A.. |
| To assess relationships between neuropeptide-binding sites and receptor proteins in rat brain, the distribution of radioautographically labeled somatostatin and neurotensin-binding sites was compared to that of immunolabeled sst2A and NTRH receptor subtypes, respectively. By light microscopy, immunoreactive sst2A receptors were either confined to neuronal perikarya and dendrites or diffusely distributed in tissue. By electron microscopy, areas expressing somatodendritic sst2A receptors displayed only low proportions of membrane-associated, as compared to intracellular, receptors. Conversely, regions displaying diffuse sst2A labeling exhibited higher proportions of membrane-associated than intracellular receptors. Furthermore, the former showed only low... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Neurotensin; Somatostatin; Internalization; Neuropeptides; Autoradiography; Ultrastructure. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000200005 |
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| Haddad,A.; Faria-e-Sousa,S.J.. |
| The purpose of this investigation was to analyze the proliferative behavior of rabbit corneal epithelium and establish if any particular region was preferentially involved in epithelial maintenance. [3H]-thymidine was injected intravitreally into both normal eyes and eyes with partially scraped corneal epithelium. Semithin sections of the anterior segment were evaluated by quantitative autoradiography. Segments with active replication (on) and those with no cell division (off) were intermingled in all regions of the tissue, suggesting that the renewal of the epithelial surface of the cornea followed an on/off alternating pattern. In the limbus, heavy labeling of the outermost layers was observed, coupled with a few or no labeled nuclei in the basal... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cornea; Epithelium; Autoradiography; Germinative cells; Stem cells; Limbus. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000600470 |
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| Stumpf,W.E.. |
| The history of receptor autoradiography, its development and applications, testify to the utility of this histochemical technique for localizing radiolabeled hormones and drugs at cellular and subcellular sites of action in intact tissues. Localization of diffusible compounds has been a challenge that was met through the introduction of the "thaw-mount" and "dry-mount" autoradiographic techniques thirty years ago. With this cellular receptor autoradiography, used alone or combined with other histochemical techniques, sites of specific binding and deposition in vivo and in vitro have been characterized. Numerous discoveries, some reviewed in this article, provided information that led to new concepts and opened new areas of research. As an example, in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Vitamin D; Steroid hormones; Receptors; Autoradiography; Drug distribution; Localization. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000200003 |
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| Alibardi, L.. |
| The development of claws in different reptiles and their cornification are analyzed using histological, ultrastructural and autoradiographic methods. Claws develop at the tip of digits in relation to the growth of the terminal phalanx and appear as modified scales. The apical epidermis of digit becomes thickened and is associated with a mesenchymal condensation or a dense mesenchyme. The dorsal side of the digit becomes the unguis while the ventral side becomes the sub-unguis. The corneous layer in the unguis is thicker than in the sub-unguis and accumulates hard-keratin while corneocytes remain separated or partially fused. Bundles of hard-keratin tend to accumulate in parallel orientation with respect to the surface and are directed toward the claw tip.... |
| Tipo: Article / Letter to the editor |
Palavras-chave: Autoradiography; Claws; Cornification; Histogenesis; Reptiles; Ultrastructure; 42.82. |
| Ano: 2009 |
URL: http://www.repository.naturalis.nl/record/304588 |
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| Pinto,R. Magalhães; Noronha,Dely; Almeida,Marília S. S; Katz,Naftale; Tendler,Miriam. |
| Skin to lung migration of Schistosoma mansoni Sambon, 1907 - (75 Se) - selenomethionine-labeled cercariae was tracked by tissue autoradiography on days 1, 4, 6, 8 after challenge, in rabbits immunized with a S. mansoni derived saline extract. Either in vaccinated animals or in those of the control unprimed group, the peak of skin schistosomula occurs 24hs after infection. Comparison between peaks of lungs migrating larvae showed that, in control animals, the increase of worm burden in this site, is detected on the 6th day post-infection, differing from immunized rabbits, in which this peak occurs on day 4, when skin and lungs counts are still equivalent, decreasing gradually, showing a different pattern of the S. mansoni migration and suggesting that main... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Schistosoma mansoni; Migration; Autoradiography; Immunization; Rabbits. |
| Ano: 1994 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-81751994000400006 |
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