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	Provedor de dados BJPS (2) Autor Ain,Md Ruhal (1) Alsultan,Mohammad Sultan (1) Araujo,Bibiana Verlindo de (1) Beck,Ruy Carlos Ruver (1) Chaves,Paula dos Santos (1) Fontana,Márcia Camponogara (1) Forgearini,Betielli (1) Govindasamy,Jeyabalan (1) Khalilullah,Habibullah (1) Khurshid,Fowad (1) Laureano,João Víctor (1) Nomani,Mohammed Shivli (1) Shahid,Mudassar (1) Mais... Palavra-chave Bioavailability. (2) Amitriptyline/pharmacokinetics (1) Bacopa monnieri/effects (1) CYP450 (1) Herbal drug interaction (1) Liquid chromatography. (1) Plasma. (1) Raloxifene/pharmacokinetic (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2017 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effect of herb-drug interactions of Bacopa monnieri Linn. (Brahmi) formulation on the pharmacokinetics of amitriptyline in rats BJPS Khurshid,Fowad; Govindasamy,Jeyabalan; Khalilullah,Habibullah; Nomani,Mohammed Shivli; Shahid,Mudassar; Ain,Md Ruhal; Alsultan,Mohammad Sultan. ABSTRACT Interactions between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Experimental data on the pharmacokinetic interactions between herbal products and drugs are limited. This study attempted to investigate the effect of Bacopa monnieri Linn. (Brahmi) formulation on the pharmacokinetics of amitriptyline in rats. In this study, rats were randomly divided into two groups (n = 6 each) which were served as a control (amitriptyline alone) and treatment group (amitriptyline with B. monnieri), respectively. Rats in the treatment group received B. monnieri (31 mg/kg/day) whereas the control group received normal saline by oral gavage for seven days before a single intragastric administration of 25... Tipo: Info:eu-repo/semantics/article Palavras-chave: Herbal drug interaction; Bacopa monnieri/effects; Amitriptyline/pharmacokinetics; CYP450; Bioavailability.. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400610 LC-UV method to assay raloxifene hydrochloride in rat plasma and its application to a pharmacokinetic study BJPS Fontana,Márcia Camponogara; Laureano,João Víctor; Forgearini,Betielli; Chaves,Paula dos Santos; Araujo,Bibiana Verlindo de; Beck,Ruy Carlos Ruver. A specific, precise, and accurate LC-UV method was developed and validated to assay raloxifene hydrochloride in rat plasma. Raloxifene was analyzed after liquid-liquid extraction and quantified by reversed phase liquid chromatography (C18 column) using acetonitrile and ammonium acetate buffer 0.05 M (pH 4.0) as mobile phase at a flow rate of 1 mL.min-1 and UV detection at 287 nm. Retention times of raloxifene and internal standard (dexamethasone) were approximately 11 min and 14 min, respectively. Linearity was checked for a concentration range between 25 ng.mL-1 and 1000 ng.mL-1. Intra- and inter-day precision had relative standard deviation lower than 10% and 15%, respectively. Recovery from plasma was higher than 90%. Accuracy values were 98.21%,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Raloxifene/pharmacokinetic; Liquid chromatography.; Plasma.; Bioavailability.. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100538 Registros recuperados: 2 Primeira ... 1 ... Última

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