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	Provedor de dados BJPS (2) Autor Amaro,Beatriz Panichi (1) Meneguetti,Giovanna Pastore (1) Monteiro,Gisele (1) Pimenta,Marcela Valente (1) Rangel-Yagui,Carlota Oliveira (1) Santos,João Henrique Picado Madalena (1) Torres-Obreque,Karin Mariana (1) Mais... Palavra-chave Biological drugs (2) Biobetters (1) Biopharmaceutical (1) Biosimilar (1) Brazilian biopharmaceutical market (1) PEGylation (1) Polyethylene glycol (1) Protein purification (1) Site-specific PEGylation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2018 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The production of biopharmaceuticals in Brazil: current issues BJPS Pimenta,Marcela Valente; Monteiro,Gisele. Biopharmaceuticals are gaining a growing share of the pharmaceuticals market. In recent years, the Brazilian Health Surveillance Agency (ANVISA) has approved the registration of biological drugs with domestic production. Although Brazil is in the early stages of biopharmaceutical production, governmental incentives and the investment in private companies in the technological domain in this country have created expectations of an increase in the capacity of biopharmaceutical production. Private initiatives, once rare, have now started to blossom in this field, such as collagenase from Cristalia and filgrastim from Eurofarm. The expiry of the patents for certain biopharmaceuticals (e.g. infliximab, filgrastim and rituximab) has generated the possibility of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Biopharmaceutical; Biosimilar; Biological drugs; Brazilian biopharmaceutical market. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100599 Protein PEGylation for the design of biobetters: from reaction to purification processes BJPS Santos,João Henrique Picado Madalena; Torres-Obreque,Karin Mariana; Meneguetti,Giovanna Pastore; Amaro,Beatriz Panichi; Rangel-Yagui,Carlota Oliveira. The covalent attachment of polyethylene glycol (PEG) to therapeutical proteins is an important route to develop biobetters for biomedical, biotech and pharmaceutical industries. PEG conjugation can shield antigenic epitopes of the protein, reduce degradation by proteolytic enzymes, enhance long-term stability and maintain or even improve pharmacokinetic and pharmacodynamics characteristics of the protein drug. Nonetheless, correct information in terms of the PEGylation process from reaction to downstream processing is of paramount importance for the industrial application and processing scale-up. In this review we present and discuss the main steps in protein PEGylation, namely: PEGylation reaction, separation of the products and final characterization of... Tipo: Info:eu-repo/semantics/article Palavras-chave: PEGylation; Biobetters; Biological drugs; Polyethylene glycol; Protein purification; Site-specific PEGylation. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000700408 Registros recuperados: 2 Primeira ... 1 ... Última

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