|
|
|
|
|
| Mondeguer, Florence; Antignac, Jean-philippe; Guitton, Yann; Monteau, Fabrice; Le Borgne, Sabrina; Hess, Philipp. |
| The bioactivity of phytoplankton toxins that accumulate in shellfish is almost always tested on animal model (mice assay). In spite of these advantages, the ability of this test to explain the nature of the bioactivity remains limited. Besides, the current sanitary control based on targeted methods of identification and quantification (LC-MS/MS) of known toxins, do not permit to detect unknown toxins. In order to cope with this need of identification of unknown toxic substances, a next approach based on global and differential metabolomic profiling was proposed. The first results obtained from extracts that have shown a positive toxicity in mice without the substances potentially responsible for these toxic effects have been measured by targeted methods,... |
| Tipo: Text |
Palavras-chave: Métabolomique; LC-HRMS; Biotoxines marines; Biomarqueur. |
| Ano: 2012 |
URL: http://archimer.ifremer.fr/doc/00077/18784/16352.pdf |
| |
|
| |
|
|
| Bocquene, Gilles. |
| Les cholinestérases et particulièrement l'acétylcholinestérase (AChE) constituent la cible privilégiée de nombreuses molécules neurotoxiques notamment des insecticides organophosphorés (OP) et carbamates. La sensibilité des cholinestérases à ces inhibiteurs est aussi complexe que le polymorphisme de ces enzymes. L'utilisation des niveaux d'activité des cholinestérases comme marqueur d'exposition aux neurotoxiques dans le milieu marin implique donc une connaissance approfondie du polymorphisme de i'enzyme, de Ja sensibilité des formes AChE identifiées et des contaminants neurotoxiques susceptibles de provoquer des variations dans l'activité de cette enzyme chez les organismes marins. Aprés une synthèse des connaissances sur le polymorphisme des... |
| Tipo: Text |
Palavras-chave: Biomarqueur; Cholinestérases; Pollution marine; Huître; Organophosphorés; Carbamates. |
| Ano: 1996 |
URL: http://archimer.ifremer.fr/doc/00443/55435/56950.pdf |
| |
|
|
| Geret, F; Cosson, Rp. |
| Heavy metals (Cd, Cu, Hg and Zn) and metallothionein levels were determined in oysters Crassostrea gigas from two sites: the Gironde Estuary (contaminated site) and Bourgneuf Bay (uncontaminated site). Metallothionein levels led us to suspect the presence of cadmium in the environment when quantified in the gills. Soluble cadmium and metallothioneins were positively correlated in the digestive gland of oysters from Gironde (contaminated site), but metallothionein levels in this organ were not significantly different from levels observed in the digestive gland of oysters from Bourgneuf Bay (uncontaminated site). Conversely, no correlation was noticed between metals and metallothioneins in the gills of oysters from Gironde despite metallothionein levels... |
| Tipo: Text |
Palavras-chave: Métallothionéines; Métaux; Crassostrea gigas; Biomarqueur; Metallothioneins; Metals; Crassostrea gigas; Biomarker. |
| Ano: 2000 |
URL: http://archimer.ifremer.fr/doc/00324/43561/44058.pdf |
| |
|
|
| Rees, Jg; Setiapermana, D; Sharp, Va; Weeks, Jm; Williams, Tm. |
| To evaluate the impact of land-based contaminants on benthic faunas, as part of the Land-Ocean Contamination Study (LOCS), a study transect was established in Jakarta Bay, Indonesia during the 1996 southeasterly monsoon. The transect extended 72 km between the city's main port, Tanjung Priok, and the Pilau Seribu Island chain in the Java Sea. The dissolved concentrations of Pb, Cu, Zn, Cr and Ni in seawater, in suspended particulate matter (SPM) and surficial sea bed sediments were measured along the transect at nine sites. In addition, metal concentrations were measured in tissues of the corals Goniopora lobata and Lobophyllia hemprichii at five sites, and of the green mussel, Perna viridis at six sites. An assessment of the impact of contaminants on the... |
| Tipo: Text |
Palavras-chave: Djakarta; Contamination; Biomarqueur; Communauté corallienne; Jakarta; Contamination; Biomarker; Coral-community. |
| Ano: 1999 |
URL: http://archimer.ifremer.fr/doc/00325/43588/44028.pdf |
| |
|
| |
|
|
| Dellali, M; Romeo, M; Aissa, P. |
| The variations of catalase activity, which is a biochemical biomarker of exposure to an oxidative stress, were followed month by month (from May 1998 to May 1999) in Mediterranean clams (Ruditapes decussatus) collected at three stations (J, A and F), and mussels (Mytilus galloprovincialis) collected at two stations (J and C) in Lake Bizerte (Tunisia). Several oceanographic parameters were measured together with catalase activity in the animals to evaluate the quality of waters in the lake. Whatever the station taken into consideration, catalase activity in clams significantly varied as a function of the season, with marked increases in September, when the quality of waters was poor. Clams originating from station A presented the highest mean activity... |
| Tipo: Text |
Palavras-chave: Biomarqueur; Catalase; Lagune de Bizerte; Moule; Palourde; Biomarker; Catalase; Lake Bizerte; Mussel; Clam. |
| Ano: 2001 |
URL: http://archimer.ifremer.fr/doc/00322/43354/42859.pdf |
| |
|
|
|
