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	Provedor de dados BJPS (1) Autor Capote,Ticiana Sidorenko de Oliveira (1) Coelho,Fernanda (1) Melchior,Karine (1) Saska,Sybele (1) Scarel-Caminaga,Raquel Mantuaneli (1) Palavra-chave BONEFILL®/toxicity (1) Biomaterials/evaluation (1) Bone regeneration (1) Hydroxyapatite. (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última BONEFILL ® block as alternative for bone substitute: a toxicological evaluation BJPS Melchior,Karine; Saska,Sybele; Coelho,Fernanda; Scarel-Caminaga,Raquel Mantuaneli; Capote,Ticiana Sidorenko de Oliveira. ABSTRACT Bone substitutes based on hydroxyapatite (HA) and Bonefill® (BO - inorganic bovine bone) associated with poly(lactic-co-glycolic acid) (PLGA) (HA/PLGA and BO/PLGA) were evaluated concerning cytotoxicity, genotoxicity and mutagenicity as potential candidates for bone repair. The materials were developed and provided by Bionnovation Biomedical Products Ltda. Eluates from these bone substitutes were prepared for toxicity evaluations using eukaryotic cell cultures. HA/PLGA was used as a comparison for Bonefill®. Cell viability was evaluated by XTT assay and surviving fraction was calculated for clonogenic survival. Additionally, tail moment was used to assess genotoxicity (comet assay). The frequencies of binucleated cells with micronucleus (FBMN),... Tipo: Info:eu-repo/semantics/article Palavras-chave: BONEFILL®/toxicity; Biomaterials/evaluation; Bone regeneration; Hydroxyapatite.. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200611 Registros recuperados: 1 Primeira ... 1 ... Última

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