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Immune response to Mycobacterium bovis-AN5 infection in genetically selected mice (selection IV-A) J. Venom. Anim. Toxins incl. Trop. Dis.
Cavaleiro,J. S.; Trindade,B. C.; Balderramas,H. A.; Haanwinckel,M. C.; Pinto,J. G. G.; Oliveira,S. L.; Paes,A. C..
Mice genetically selected for high (H) and low (L) antibody production (Selection IV-A) were used as murine experimental model. The aim of the present work was to evaluate the macrophagic activity and to characterize the immune response in Mycobacterium bovis-AN5 infected mice (3X10(7) bacteria). The response profile previously observed in such strains was not similar to that obtained during M. bovis infection; however, it corroborated works carried out using Selection I, which is very similar to Selection IV-A regarding infection by M. tuberculosis and Bacillus Calmette-Guérin (BCG). Considering bacterial recovery, L IV-A mice showed higher control of the infectious process in the lungs than in the spleen, whereas H IV-A mice presented more resistance in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Immune response; Mycobacterium bovis; Biozzi mice.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000300006
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Production of reactive oxygen (H2O2) and nitrogen (NO) intermediates and TNF-α in mice genetically selected for high (H) and low (L) antibody response and experimentally infected with Leptospira serovar pomona BJM
Haanwinckel,Maria Cristina Santos; Oliveira,Silvio Luis de.
The aim of the present study was to evaluate the activity of macrophages, and the production of TNF-α and antibodies against experimental infection by Leptospira serovar Pomona in mice genetically selected for High (H) or Low (L) humoral immune response. To evaluate macrophagic activity, peritoneal and splenic lavages were performed for determination of oxygen (H2O2) and nitrogen (NO) intermediates. The production of the tumor necrosis factor (TNF-α) was investigated through bioassays in serum and homogenates of splenic and hepatic cells of control and infected animals, as was as specific antibodies production. The immune response against serovar Pomona in those lines, was characterized by high antibody production, especially in later periods of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Immunological aspects; Biozzi mice; Leptospira; Macrophages; Cytokines.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000200041
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