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Assessment of fibrosis and vascularization of bone marrow stroma of chronic myeloid Leukemia patients treated with imatinib mesylate and their relationship with the cytogenetic response BJPS
Jesus,Caroline Regina de; I-Ching,Lee; Neiva,Teresinha de Jesus Carvalho; Vituri,Cidônia de Lourdes.
Chronic Myeloid Leukemia (CML) is a myeloproliferative disease characterized by the presence of the Philadelphia chromosome (translocation between chromosomes 9 and 22), resulting in the formation of the hybrid BCR-ABL protein. Currently, the treatment of CML patients is performed with imatinib mesylate (IM), which promotes the elimination of leukemic cells by inhibiting the kinase activity of BCR-ABL. This study evaluated the effectiveness of IM by monitoring 22 CML patients in a chronic phase treated at the CEPON/SC with IM for a minimum follow-up period of two years. Cytogenetic Response (CR) and bone marrow biopsies (BMB) were evaluated before and after IM treatment. BMB were evaluated by detection of reticulin degree and vascularization. The results...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic myeloid leukemia/treatment; Imatinib mesylate/effectiveness; Imatinib mesylate/leukemia treatment; Bone marrow/biopsies; Fibrosis; Vascularization.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200012
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