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	Provedor de dados 74 (2) Autor Acosta,Angelina Xavier (2) Galvão-Castro,Bernardo (2) Brites,Carlos (1) Cabral-Oliveira,Fernando Cézar (1) Grimaldi,Rogério (1) Sampaio,Rogério Grimaldi (1) Spínola,Juliana Lima (1) Mais... Palavra-chave Brazilian populations (2) CCR2-64I mutation (1) CCR5 gene (1) HIV co-receptor (1) HIV-1 (1) M303 frequency (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2005 (1) 2003 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Distribution of the CCR2-64I allele in three Brazilian ethnic groups 74 Acosta,Angelina Xavier; Sampaio,Rogério Grimaldi; Spínola,Juliana Lima; Galvão-Castro,Bernardo. CCR2 is a member of the superfamily of seven transmembrane domain G protein-coupled receptors, the largest receptor superfamily in the human genome. CCR2 acts as a receptor for MCP-1 (CC chemokine) and as a co-receptor for HIV-1 cell-target entry. The gene encoding this receptor is mapped to the chromosome band 3p21. A G-to-A transition at position 190 characterizes the CCR2-64I mutation, causing valine to isoleucine substitution in codon 64. This mutation has been identified as an important factor for delaying progression to AIDS. Here, we determined the prevalence of this allele in three different Brazilian populations: 261 Amerindians inhabiting an isolated region in northern Brazil (82 samples from the Waiampi tribe, and 179 samples from the Tiriyó... Tipo: Info:eu-repo/semantics/article Palavras-chave: CCR2-64I mutation; Brazilian populations; HIV co-receptor. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000300004 Study of the CCR5-m303 mutation in three different ethnic groups from Brazil 74 Grimaldi,Rogério; Acosta,Angelina Xavier; Cabral-Oliveira,Fernando Cézar; Brites,Carlos; Galvão-Castro,Bernardo. The main coreceptor gene involved in HIV-1 infection is CCR5 beta chemokine receptor gene for which several mutations have been described, some of which have correlated with HIV-1 infection, acquired immune deficiency syndrome (AIDS), or both. Deletion of 32bp in the CCR5 gene (delta32) has been shown to confer resistance to infection by HIV-1 R5 strains. Another mutation, characterized by a thymine to adenine (T to A) nucleotide substitution at position 303 (m303), has shown the same effects as the delta32 mutation, with previous studies having shown that the allele frequency of the CCR5-m303 mutation is 0.014 in African-American and 0.007 in French populations. The Brazilian population is known to be genetically diverse, because of which we investigated... Tipo: Info:eu-repo/semantics/other Palavras-chave: CCR5 gene; M303 frequency; Brazilian populations; HIV-1. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000200006 Registros recuperados: 2 Primeira ... 1 ... Última

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