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	Provedor de dados BJMBR (2) Autor Cao,Y. (1) Chen,Q. (1) Fang,Y. (1) Ge,Yinlin (1) Hou,Lin (1) Li,H. (1) Long,L. (1) Qin,R. (1) Shen,H. (1) Wang,Qing (1) Xie,C.J. (1) Xu,W.L. (1) Xue,Meilan (1) Zhang,Jinyu (1) Zhu,X.L. (1) Mais... Palavra-chave Breast cancer cells (2) Chlorella vulgaris (1) CvFad3 gene (1) Doxorubicin resistance (1) Fatty acid composition (1) Fatty acid desaturase (1) MiR-30c (1) Recombinant expression vector (1) YWHAZ (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 2012 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Involvement of miR-30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells BJMBR Fang,Y.; Shen,H.; Cao,Y.; Li,H.; Qin,R.; Chen,Q.; Long,L.; Zhu,X.L.; Xie,C.J.; Xu,W.L.. MicroRNAs (miRNAs) are small RNA molecules that modulate gene expression implicated in cancer, which play crucial roles in diverse biological processes, such as development, differentiation, apoptosis, and proliferation. The aim of this study was to investigate whether miR-30c mediated the resistance of breast cancer cells to the chemotherapeutic agent doxorubicin (ADR) by targeting tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ). miR-30c was downregulated in the doxorubicin-resistant human breast cancer cell lines MCF-7/ADR and MDA-MB-231/ADR compared with their parental MCF-7 and MDA-MB-231 cell lines, respectively. Furthermore, we observed that transfection of an miR-30c mimic significantly suppressed the ability of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Breast cancer cells; MiR-30c; YWHAZ; Doxorubicin resistance. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000100060 Gene transfer of Chlorella vulgaris n-3 fatty acid desaturase optimizes the fatty acid composition of human breast cancer cells BJMBR Xue,Meilan; Ge,Yinlin; Zhang,Jinyu; Wang,Qing; Hou,Lin. Chlorella vulgaris has the gene of n-3 fatty acid desaturase (CvFad3), which can synthesize the precursor of n-3 polyunsaturated fatty acids (PUFAs) or convert n-6 to n-3 PUFAs. The objective of the present study was to examine whether the CvFad3 gene from C. vulgaris can be functionally and efficiently expressed in human breast cancer cells and whether its expression can exert a significant effect on cell fatty acid composition. We inserted the CvFad3 gene into the plasmid pEGFP-C3 to construct the eukaryotic expression vector pEGFP-C3-n-3 and to express the n-3 Fad gene in human breast cancer cells (MCF-7 cells). Transfection of MCF-7 cells with the recombinant vector resulted in a high expression of n-3 fatty acid desaturase. Lipid analysis indicated... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chlorella vulgaris; CvFad3 gene; Fatty acid desaturase; Recombinant expression vector; Fatty acid composition; Breast cancer cells. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200006 Registros recuperados: 2 Primeira ... 1 ... Última

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