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CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast Biol. Res.
García-Labastida,Laura; Garza-Guajardo,Raquel; Barboza-Quintana,Oralia; Rodríguez-Sanchez,Irám Pablo; Ancer-Rodríguez,Jesús; Flores-Gutierrez,Juan Pablo; Gómez-Macías,Gabriela Sofía.
BACKGROUND: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma. RESULTS: Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. CONCLUSIONS: These results suggest that mucinous breast carcinomas express some...
Tipo: Journal article Palavras-chave: Breast mucinous carcinoma; Inmunohistochemical; Intestinal differentiation.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100043
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