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	Provedor de dados BJPS (1) Genet. Mol. Biol. (1) Autor Andrade,Fabiana A. de (1) Arshad,Muhammad (1) Ayub,Khurshid (1) Bono,Gleyse F. (1) Brandão,Mariana B. (1) Chautard-Freire-Maia,Eleidi A. (1) Ejaz,Asma (1) Faria,Ana Cristina R. de A. (1) Farooq,Ariba (1) Furtado-Alle,Lupe (1) Gilani,Mazhar Amjad (1) Guimarães,Larissa O. (1) Kumar,Anupriya (1) Ninomiya,Ichiya (1) Picheth,Geraldo (1) Réa,Rosângela R. (1) Santos,Izabella C.R. dos (1) Setoguchi,Thaís E. (1) Souza,Ricardo L.R. (1) Yar,Muhammad (1) Mais... Palavra-chave Butyrylcholinesterase (BChE) (2) -116A variant (1) 1615A variant (1) Acetylcholinesterase (AChE) (1) Alzheimer's disease (1) Antioxidant compounds (1) Chronic diseases (1) Computational studies (1) DPPH assay (1) Density Functional Theory (1) Gestational diabetes mellitus (1) Indole derivatives (1) Molecular docking (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2015 (1) 2014 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Synthesis and DPPH scavenging assay of reserpine analogues, computational studies and in silico docking studies in AChE and BChE responsible for Alzheimer's disease BJPS Yar,Muhammad; Arshad,Muhammad; Farooq,Ariba; Gilani,Mazhar Amjad; Ayub,Khurshid; Ejaz,Asma; Kumar,Anupriya; Ninomiya,Ichiya. Alzheimer's disease (AD) is a fast growing neurodegenerative disorder of the central nervous system and anti-oxidants can be used to help suppress the oxidative stress caused by the free radicals that are responsible for AD. A series of selected synthetic indole derivatives were biologically evaluated to identify potent new antioxidants. Most of the evaluated compounds showed significant to modest antioxidant properties (IC50 value 399.07 140.0±50 µM). Density Functional Theory (DFT) studies were carried out on the compounds and their corresponding free radicals. Differences in the energy of the parent compounds and their corresponding free radicals provided a good justification for the trend found in their IC50 values. In silico, docking of compounds into... Tipo: Info:eu-repo/semantics/article Palavras-chave: Alzheimer's disease; Antioxidant compounds; Chronic diseases; Density Functional Theory; Molecular docking; Computational studies; DPPH assay; Indole derivatives; Acetylcholinesterase (AChE); Butyrylcholinesterase (BChE). Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100053 Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids Genet. Mol. Biol. Guimarães,Larissa O.; Andrade,Fabiana A. de; Bono,Gleyse F.; Setoguchi,Thaís E.; Brandão,Mariana B.; Chautard-Freire-Maia,Eleidi A.; Santos,Izabella C.R. dos; Picheth,Geraldo; Faria,Ana Cristina R. de A.; Réa,Rosângela R.; Souza,Ricardo L.R.; Furtado-Alle,Lupe. Many conditions interfere with butyrylcholinesterase (BChE) activity, e.g., pregnancy or presence of the BCHE gene variant -116A can decrease activity whereas obesity and types I and II diabetes mellitus can increase activity. In this study, we examined BChE activity, -116A and 1615A BCHE gene variants, and anthropometric and biochemical variables associated with diabetes in patients with gestational diabetes mellitus (GDM) and in healthy pregnant women. BChE activity was measured spectrophotometrically using propionylthiocholine as substrate and genotyping of the -116 and 1615 sites of the BCHE gene was done with a TaqMan SNP genotyping assay. Three groups were studied: 150 patients with GDM, 295 healthy pregnant women and 156 non-pregnant healthy women.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Butyrylcholinesterase (BChE); Gestational diabetes mellitus; -116A variant; 1615A variant. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000100003 Registros recuperados: 2 Primeira ... 1 ... Última

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