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	Provedor de dados BJMBR (2) OAK (1) Anais da ABC (AABC) (1) Autor Alberti,C. (1) Bi,S.C. (1) Cartier,L. (1) DOSREIS,GEORGE A. (1) Iguchi, Aiko (1) Li,Z. (1) Ma,R. (1) Mai,T.J. (1) Miyahara, Kazuro (1) Rodriguez,L. (1) Shimbo, Genya (1) Tagawa, Michihito (1) Tomihari, Mizuki (1) Valenzuela,M.A. (1) Xuan, Xuenan (1) Yamamoto, Yuhei (1) Mais... Palavra-chave CTLA-4 (4) Apoptosis (1) CD152 (1) DNA vaccine (1) Dog (1) Foxp3 (1) GITR mRNA expression (1) HTLV-1-associated myelopathy/tropical spastic paraparesis (1) Leishmania chagasi (1) PSCA (1) Prostate cancer (1) Soluble form (1) Splicing variant (1) T lymphocytes (1) Tax (1) Transforming growth factor (1) Trypanosoma cruzi (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2017 (1) 2016 (1) 2010 (1) 2000 (1) País Brazil (3) Japan (1) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Gene and protein expression of a soluble form of CTLA-4 in a healthy dog OAK Tagawa, Michihito; Yamamoto, Yuhei; Shimbo, Genya; Iguchi, Aiko; Xuan, Xuenan; Tomihari, Mizuki; Miyahara, Kazuro. Cytotoxic T lymphocyte associated gene-4 (CTLA-4) is a costimulatory molecule, expressed on the surface of activated T cells that negatively regulates T cell activation. In humans, alternative splicing of the CTLA-4 gene generates two major isoforms of mRNA, and a soluble form of CTLA-4 (sCTLA-4) was detected in normal human serum. We describe alternatively spliced mRNA expressed in peripheral blood mononuclear cells obtained from a healthy dog lacking the transmembrane domain coded by exon 3 of the CTLA-4 gene. Immunoprecipitation and western blotting of dog serum revealed a band of approximately 23-kDa, which is consistent with the predicted size, based on the amino acid sequence of the canine sCTLA-4 obtained in this study. Palavras-chave: CD152; CTLA-4; Dog; Soluble form; Splicing variant. Ano: 2017 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4517 Susceptible hosts: a resort for parasites right in the eye of the immune response Anais da ABC (AABC) DOSREIS,GEORGE A.. Trypanosomatid protozoan parasites express an aggressive strategy of parasitism by infecting host macrophages and inducing extensive T-lymphocyte activation. One goal of such strategy is to drive the immune response of genetically susceptible hosts to a state of unresponsiveness regarding parasite killing. Unresponsiveness is achieved through different mechanisms, depending on the parasite species. In this brief review, recent findings on the molecular and cellular bases of the parasites' exploitation of host immune responses are discussed. Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Leishmania chagasi; T lymphocytes; CTLA-4; Apoptosis; Transforming growth factor. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000100011 Construction of a fusion plasmid containing the PSCA gene and cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and its anti-tumor effect in an animal model of prostate cancer BJMBR Mai,T.J.; Ma,R.; Li,Z.; Bi,S.C.. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T cell activation, which competes with CD28 for B7.1/B7.2 binding, and which has a greater affinity. Fusion of specific antigens to extracellular domain of CTLA4 represents a promising approach to increase the immunogenicity of DNA vaccines. In this study, we evaluated this interesting approach for CTLA4 enhancement on prostate stem cell antigen (PSCA)-specific immune responses and its anti-tumor effects in a prostate cancer mouse model. Consequently, we constructed a DNA vaccine containing the PSCA and the CTLA-4 gene. Vaccination with the CTLA4-fused DNA not only induced a much higher level of anti-PSCA antibody, but also increased PSCA-specific T cell response in mice. To... Tipo: Info:eu-repo/semantics/article Palavras-chave: Prostate cancer; DNA vaccine; PSCA; CTLA-4. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001100601 In vivo fluctuation of Tax, Foxp3, CTLA-4, and GITR mRNA expression in CD4+CD25+ T cells of patients with human T-lymphotropic virus type 1-associated myelopathy BJMBR Cartier,L.; Rodriguez,L.; Alberti,C.; Valenzuela,M.A.. HTLV-1 Tax expression exerts an inhibitory effect on the Foxp3 transcription factor in CD4+CD25+ T-regulatory cells (Treg). For a better understanding of the role of Tax mRNA in the gene expression of cellular markers we measured Tax, Foxp3, CTLA-4, GITR, TGF-β, and IL-10 mRNA in Treg cells of 50 patients with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP; 27 women and 23 men; mean age: 56.7 years). The control group consisted of 23 non-infected subjects (12 women and 11 men) with a mean age of 51.3 years. Real-time PCR was used to measure mRNA of Tax proteins and several cellular markers of Treg function. Determinations revealed a high level of Tax mRNA in HAM/TSP (124.35 copies/100 CD4+CD25+ T... Tipo: Info:eu-repo/semantics/article Palavras-chave: HTLV-1-associated myelopathy/tropical spastic paraparesis; Tax; Foxp3; CTLA-4; GITR mRNA expression. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100014 Registros recuperados: 4 Primeira ... 1 ... Última

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