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Chemokines in the cerebrospinal fluid of patients with active and stable relapsing-remitting multiple sclerosis BJMBR
Moreira,M.A.; Souza,A.L.S.; Lana-Peixoto,M.A.; Teixeira,M.M.; Teixeira,A.L..
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the human central nervous system. Although its etiology is unknown, the accumulation and activation of mononuclear cells in the central nervous system are crucial to its pathogenesis. Chemokines have been proposed to play a major role in the recruitment and activation of leukocytes in inflammatory sites. They are divided into subfamilies on the basis of the location of conserved cysteine residues. We determined the levels of some CC and CXC chemokines in the cerebrospinal fluid (CSF) of 23 relapsing-remitting MS patients under interferon-ß-1a therapy and 16 control subjects using ELISA. MS patients were categorized as having active or stable disease. CXCL10 was significantly...
Tipo: Info:eu-repo/semantics/article Palavras-chave: CXCL10; CCL2; Inflammation; Multiple sclerosis; Leukocyte recruitment.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400003
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