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| Kolovou,Genovefa; Kolovou,Vana; Ragia,Georgia; Mihas,Constantinos; Diakoumakou,Olga; Vasiliadis,Ioannis; Mavrogeni,Sophie; Vartela,Vassiliki; Manolopoulos,Vangelis G. |
| In this work, we examined the impact of polymorphism in the cytochrome P450 (CYP) 3A5 gene, CYP3A5*1 (6986A > G, rs 776746), on the reduction in the lipid levels caused by simvastatin and atorvastatin. We studied 350 hyperlipidemic patients who received 10-40 mg of atorvastatin (n = 175) or simvastatin (n = 175) daily. Genotyping for CYP3A5 was done by PCR-RFLP analysis. Differences in the lipid profile before and after treatment were expressed as the % difference. The frequency of CYP3A5 polymorphism was 13.4% for heterozygotes and 86.6% for homozygotes. Comparison of the responses to same dose of each drug showed that the highest % difference was associated with total cholesterol (TC) in subjects receiving atorvastatin 40 mg compared with simvastatin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Atorvastatin; Cholesterol; CYP3A5 gene polymorphism; Simvastatin. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000200129 |
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