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	Provedor de dados Biol. Res. (2) BJMBR (1) Autor GYÖRKE,INNA (1) GYÖRKE,SANDOR (1) Masuda,M.O. (1) Oliveira-Castro,G.M. (1) RÍOS,EDUARDO (1) Saraiva,R.M. (1) TERENTYEV,DMITRY (1) VIATCHENKO-KARPINSKI,SERGE (1) WILLIAMS,SIMON C (1) ZHOU,JINGSONG (1) Mais... Palavra-chave Calcium-induced calcium release (3) Excitation-contraction coupling (2) Ryanodine receptor (2) Arrhythmia (1) Ca2+ ATPase (1) Ca2+ sparks (1) Ca2+-dependent K+ current (1) Calsequestrin (1) Macrophage (1) Macrophage polykaryon (1) Membrane potential oscillations (1) Sarcoplasmic reticulum (1) Mais... Tipo do documento Journal article (2) Info:eu-repo/semantics/article (1) Ano 2004 (2) 1997 (1) País Chile (2) Brazil (1) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Modulation of sarcoplasmic reticulum calcium release by calsequestrin in cardiac myocytes Biol. Res. GYÖRKE,SANDOR; GYÖRKE,INNA; TERENTYEV,DMITRY; VIATCHENKO-KARPINSKI,SERGE; WILLIAMS,SIMON C. Calsequestrin (CASQ2) is a high capacity Ca-binding protein expressed inside the sarcoplasmic reticulum (SR). Mutations in the cardiac calsequestrin gene (CASQ2) have been linked to arrhythmias and sudden death induced by exercise and emotional stress. We have studied the function of CASQ2 and the consequences of arrhythmogenic CASQ2 mutations on intracellular Ca signalling using a combination of approaches of reverse genetics and cellular physiology in adult cardiac myocytes. We have found that CASQ2 is an essential determinant of the ability of the SR to store and release Ca2+ in cardiac muscle. CASQ2 serves as a reservoir for Ca2+ that is readily accessible for Ca2+-induced Ca2+ release (CICR) and also as an active Ca2+ buffer that modulates the local... Tipo: Journal article Palavras-chave: Excitation-contraction coupling; Calcium-induced calcium release; Ryanodine receptor; Calsequestrin; Arrhythmia. Ano: 2004 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400014 Control of dual isoforms of Ca2+ release channels in muscle Biol. Res. RÍOS,EDUARDO; ZHOU,JINGSONG. Here we compare excitation-contraction coupling in single muscle cells of frogs and rats. Because amphibians have isoform 3 (or b) of the ryanodine receptor/Ca2+ release channel, in addition to 1 (a), which is also present in the mammal, any extra feature present in the frog may in principle be attributed to isoform 3. Ca2+ release under voltage clamp depolarization has a peak and a steady phase in both taxonomic classes, but the peak is more marked in the frog, where the ratio of amplitudes of the two phases is voltage-dependent. This dependence is a hallmark of CICR. Confocal imaging identified Ca2+ sparks in the frog, but not in the voltage-clamped rat cells. Because Ca2+ sparks involve CICR both observations indicate that the contribution of CICR is... Tipo: Journal article Palavras-chave: Excitation-contraction coupling; Sarcoplasmic reticulum; Ca2+ sparks; Ryanodine receptor; Calcium-induced calcium release. Ano: 2004 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400012 Outward potassium current oscillations in macrophage polykaryons: extracellular calcium entry and calcium-induced calcium release BJMBR Saraiva,R.M.; Masuda,M.O.; Oliveira-Castro,G.M.. Outward current oscillations associated with transient membrane hyperpolarizations were induced in murine macrophage polykaryons by membrane depolarization in the absence of external Na+. Oscillations corresponded to a cyclic activation of Ca2+-dependent K+ currents (IKCa) probably correlated with variations in intracellular Ca2+ concentration. Addition of external Na+ (8 mM) immediately abolished the outward current oscillations, suggesting that the absence of the cation is necessary not only for their induction but also for their maintenance. Oscillations were completely blocked by nisoldipine. Ruthenium red and ryanodine reduced the number of outward current cycles in each episode, whereas quercetin prolonged the hyperpolarization 2- to 15-fold. Neither... Tipo: Info:eu-repo/semantics/article Palavras-chave: Macrophage; Macrophage polykaryon; Ca2+-dependent K+ current; Membrane potential oscillations; Calcium-induced calcium release; Ca2+ ATPase. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001100015 Registros recuperados: 3 Primeira ... 1 ... Última

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